Phosphatidylcholine bearing 6,6-dideuterated oleic acid: A useful solid-state 2H NMR probe for investigating membrane properties

被引：10

作者：

Cui, Jin ^{[1
,2
,3
]}

Lethu, Sebastien ^{[1
,2
,3
]}

Yasuda, Tomokazu ^{[1
]}

Matsuoka, Shigeru ^{[1
,2
,3
]}

Matsumori, Nobuaki ^{[1
]}

Sato, Fuminori ^{[2
,3
]}

Murata, Michio ^{[1
,2
,3
]}

机构：

[1] Osaka Univ, Dept Chem, Toyonaka, Osaka 5600043, Japan

[2] Osaka Univ, Lipid Active Struct Project, ERATO, JST, Toyonaka, Osaka 5600043, Japan

[3] Osaka Univ, Project Res Ctr Fundamental Sci, Toyonaka, Osaka 5600043, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2015年 / 25卷 / 02期

关键词：

Lipid raft; Phase separation; Phosphatidylcholine; Solid-state H-2 NMR; LIPID RAFTS; PHASE-DIAGRAM; DIHYDROSPHINGOMYELIN; SPHINGOMYELIN; HIV-1; HYDRATION; BILAYERS;

D O I：

10.1016/j.bmcl.2014.11.072

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Lipid organization has been at the center of research on lipid rafts. Dioleoylphosphatidylcholine (DOPC) is a typical unsaturated lipid. Very few studies have reported its thermodynamics in raft-like membranes. Herein, we have developed a highly efficient synthetic method for [C6-H-2(2)] oleic acid, and newly synthesized [C6-H-2(2)] DOPC. In raft-like oriented bilayers, [C6-H-2(2)] DOPC shows clear phase separation and characteristic phase behavior at various temperature. It has been successfully utilized for the comparison of membrane properties between sphingomyelin (SM) and dihydrosphingomyelin (DHSM) membranes. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：203 / 206

页数：4

共 46 条

[41] Acidic Centers on the Surface of a Crystalline α-Sn(IV) Phosphate Characterized by the Solid-State 1H, 2H, 31P, and 119Sn MAS NMR Techniques (vol 6, pg 17759, 2022)
Bakhmutov, Vladimir I.
Elliott, Douglas W.
Contreras-Ramirez, Aida
Drake, Hannah
Zhou, Hong-Cai
INORGANIC CHEMISTRY, 2024, 63 (19) : 8988 - 8988
[42] Benzene-d6 and toluene-d8 as guest molecules in micropores of a layered zirconium phosphonate: 2H, 13C{1H}, and 31P{1H} solid-state NMR, deuterium NMR relaxation, and molecular motions
Contreras, Aida R.
Bakhmutov, Vladimir I.
Elliott, Douglas W.
Clearfield, Abraham
MAGNETIC RESONANCE IN CHEMISTRY, 2018, 56 (12) : 1158 - 1167
[43] The angles between the C1-, C5-, and C9-methyl bonds of the retinylidene chromophore and the membrane normal increase in the M intermediate of bacteriorhodopsin:: Direct determination with solid-state 2H NMR
Moltke, S
Wallat, I
Sakai, N
Nakanishi, K
Brown, MF
Heyn, MP
BIOCHEMISTRY, 1999, 38 (36) : 11762 - 11772
[44] Multinuclear solid-state NMR characterization of the Bronsted/Lewis acid properties in the BP HAMS-1B (H-[B]-ZSM-5) borosilicate molecular sieve using adsorbed TMPO and TBPO probe molecules
Wiper, Paul V.
Amelse, Jeffrey
Mafra, Luis
JOURNAL OF CATALYSIS, 2014, 316 : 240 - 250
[45] New glycerol-deuterated di-ether sn-1,3 phospholipids designed for 2D crystallization of soluble proteins:: Glycerol conformations and lateral diffusion properties as seen by 2H and 31P solid-state NMR
André, F
Pinet, E
Arbogast-Nuss, S
Lebeau, L
Mioskovski, C
BIOPHYSICAL JOURNAL, 1998, 74 (02) : A311 - A311
[46] (4S,7R)-7,8,8-TRIMETHYL-4,5,6,7-TETRAHYDRO-4,7-METHANO-1H(2H)-INDAZOLE (CAMPHO[2,3-C]PYRAZOLE) - COMPARISON BETWEEN THE X-RAY STRUCTURE AND C-13 NMR DATA IN THE SOLID-STATE
LLAMASSAIZ, AL
FOCESFOCES, C
SOBRADOS, I
ELGUERO, J
MEUTERMANS, W
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY, 1993, 49 : 724 - 729

← 1 2 3 4 5 →