High glucose promotes cell proliferation and enhances GDNF and RET expression in pancreatic cancer cells

被引：54

作者：

Liu, Han ^{[1
]}

Ma, Qingyong ^{[1
]}

Li, Junhui ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Dept Hepatobiliary Surg, Affiliated Hosp 1, Xian 710061, Peoples R China

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 2011年 / 347卷 / 1-2期

关键词：

GDNF; RET; High glucose; Pancreatic cancer; Proliferation; NERVE GROWTH-FACTOR; NEUROTROPHIC FACTOR; DIABETES-MELLITUS; RISK-FACTORS; INVASION; EPIDEMIOLOGY; INVOLVEMENT; ACTIVATION; INCREASES; OBESITY;

D O I：

10.1007/s11010-010-0617-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Hyperglycemia promotes pancreatic cancer progression, while the underlying mechanism is uncertain. We investigated the cell proliferation, glial cell line-derived neuotrophic factor (GDNF) and its tyrosine kinase receptor RET expression in BxPC-3 and MIA PaCa-2 cells when exposed to different concentrations of glucose. Proliferation of both cells was effected by glucose in a concentration-dependent manner. Definite expression of GDNF and RET was detected in both cells. Glucose concentrations could alter the expression of GDNF and RET in a concentration-dependent manner, correspondingly with the alterations of cell proliferation. Up-regulation of GDNF and RET ligand-receptor interaction might participate in the glucose-induced cancer progression.

引用

页码：95 / 101

页数：7

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