Gene related to stroke in stroke-prone spontaneously hypertensive rats

被引：1
|
作者：
Ikeda, K
Yamori, Y
机构：
[1] Kyoto Univ, Grad Sch Human & Environm Studies, Otsuka Dept Int Prevent Nutr Med, Kyoto 606, Japan
[2] Kyoto Univ, Grad Sch Human & Environm Studies, Otsuka Dept Int Prevent Med, Kyoto 606, Japan
来源：
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1999年 / 26卷 / 07期
关键词：
blood pressure; gene; stroke; stroke-prone spontaneously hypertensive rats;
D O I：
10.1046/j.1440-1681.1999.03087.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. In order to study genes related to stroke in stroke-prone spontaneously hypertensive rats (SHRSP), linkage analysis was performed using F2 rats (SHRSP/Izm x WKY/Izm). The brainweight that reflected cerebral stroke in F2 rats showed cosegregation with three genetic markers, D4Mit19 (P < 0.0015), D4Mgh7 (P < 0.0014) and D4Mgh8 (P < 0.004) on chromosome 4, but not blood pressure. 2. These results suggest that a chromosomal region other than the region responsible for hypertension contributes to the development of stroke in SHRSP.
引用
收藏
页码：566 / 567
页数：2
相关论文
共 50 条
  • [41] THE SPREAD OF THE BRAIN EDEMA IN SPONTANEOUSLY HYPERTENSIVE STROKE-PRONE RATS
    FREDRIKSSON, K
    KALIMO, H
    NORDBORG, C
    JOHANSSON, B
    [J]. ACTA NEUROLOGICA SCANDINAVICA, 1986, 73 (01): : 90 - 90
  • [42] CHANGES IN CARDIAC NOREPINEPHRINE IN SPONTANEOUSLY HYPERTENSIVE AND STROKE-PRONE RATS
    HOWE, PRC
    PROVIS, JC
    WEST, MJ
    CHALMERS, JP
    [J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1979, 1 (01) : 115 - 122
  • [43] ANTIHYPERTENSIVE AND RENIN EFFECTS OF STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS
    WATANABE, TX
    KAWASHIMA, K
    SOKABE, H
    [J]. FOLIA PHARMACOLOGICA JAPONICA, 1980, 76 (01) : P19 - P20
  • [44] THERAPY OF DISEASED STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS WITH NIMODIPINE
    LENZ, P
    LUCKHAUS, G
    STASCH, JP
    KAZDA, S
    [J]. STROKE, 1990, 21 (12) : 111 - 112
  • [45] Hypolipidemic effect of taurine in stroke-prone spontaneously hypertensive rats
    Murakami, S
    Yamagishi, I
    Asami, Y
    Ohta, Y
    Toda, Y
    Nara, Y
    Yamori, Y
    [J]. PHARMACOLOGY, 1996, 52 (05) : 303 - 313
  • [46] EMOTIONAL-STRESS IN THE DEVELOPMENT OF STROKE IN STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS (SHRSP)
    HORIE, R
    YAMORI, Y
    NARA, Y
    KIHARA, M
    SAWAMURA, M
    IKEDA, K
    [J]. NEW HORIZONS IN PREVENTING CARDIOVASCULAR DISEASES, 1989, 815 : 19 - 22
  • [47] Proteomic identification of haptoglobin as a stroke plasma biomarker in spontaneously hypertensive stroke-prone rats
    Kiga, Chizuru
    Sakurai, Hiroaki
    Goto, Hirozo
    Hayashi, Kazuko
    Shimada, Yutaka
    Saiki, Ikuo
    [J]. LIFE SCIENCES, 2008, 83 (17-18) : 625 - 631
  • [48] EFFECTS OF PROSTAGLANDIN INHIBITORS ON THE ONSET OF PROTEINURIA AND STROKE IN STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS
    NAGAOKA, A
    KAKIHANA, M
    IWATSUKA, H
    [J]. JAPANESE JOURNAL OF PHARMACOLOGY, 1981, 31 (01): : 125 - 127
  • [49] THROMBOXANE-A2 IN SEVERE HYPERTENSION AND STROKE IN STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS
    STIER, CT
    BENTER, IF
    LEVINE, S
    [J]. STROKE, 1988, 19 (09) : 1145 - 1150
  • [50] Interleukin-1β Accelerates the Onset of Stroke in Stroke-Prone Spontaneously Hypertensive Rats
    Chiba, Tsuyoshi
    Itoh, Tatsuki
    Tabuchi, Masaki
    Nakazawa, Toru
    Satou, Takao
    [J]. MEDIATORS OF INFLAMMATION, 2012, 2012
12345