Gene related to stroke in stroke-prone spontaneously hypertensive rats

被引：1
|
作者：
Ikeda, K
Yamori, Y
机构：
[1] Kyoto Univ, Grad Sch Human & Environm Studies, Otsuka Dept Int Prevent Nutr Med, Kyoto 606, Japan
[2] Kyoto Univ, Grad Sch Human & Environm Studies, Otsuka Dept Int Prevent Med, Kyoto 606, Japan
来源：
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1999年 / 26卷 / 07期
关键词：
blood pressure; gene; stroke; stroke-prone spontaneously hypertensive rats;
D O I：
10.1046/j.1440-1681.1999.03087.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. In order to study genes related to stroke in stroke-prone spontaneously hypertensive rats (SHRSP), linkage analysis was performed using F2 rats (SHRSP/Izm x WKY/Izm). The brainweight that reflected cerebral stroke in F2 rats showed cosegregation with three genetic markers, D4Mit19 (P < 0.0015), D4Mgh7 (P < 0.0014) and D4Mgh8 (P < 0.004) on chromosome 4, but not blood pressure. 2. These results suggest that a chromosomal region other than the region responsible for hypertension contributes to the development of stroke in SHRSP.
引用
收藏
页码：566 / 567
页数：2
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