Synthesis of carbon-11 labeled sulfonanilide analogues as new potential PET agents for imaging of aromatase in breast cancer

被引：26
|
作者：
Wang, Min
Lacy, Gabrielle
Gao, Mingzhang
Miller, Kathy D.
Sledge, George W.
Zheng, Qi-Huang [1 ]
机构：
[1] Indiana Univ, Sch Med, Dept Radiol, Indianapolis, IN 46202 USA
[2] Indiana Univ, Sch Med, Dept Med, Indianapolis, IN 46202 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 02期
关键词：
sulfonanilide analogues; carbon-11; positron emission tomography (PET); aromatase; breast cancer;
D O I：
10.1016/j.bmcl.2006.10.065
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Aromatase is a particularly good target in the treatment of estrogen receptor positive breast cancer. Novel carbon-11 labeled sulfonanilide analogues, N-[C-11]methyl-N-(2-alkyloxy-4-nitrophenyl)-methanesulfonamides ([C-11]3a-f, alkyl = propyl, isopropyl, 1-ethyl-propyl, cyclopentyl, cyclohexyl, and cyclohexylethyl), were designed and synthesized as potential PET agents for imaging of aromatase in breast cancer. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：332 / 336
页数：5
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