Association Between MGMT Promoter Hypermethylation and p53 Mutation in Glioblastoma

被引：30

作者：

Shamsara, Jamal ^{[2
]}

Sharif, Samaneh

Afsharnezhad, Sima ^{[5
]}

Lotfi, Marzieh ^{[3
]}

Raziee, Hamid Reza ^{[4
]}

Ghaffarzadegan, Kamran ^{[3
]}

Moradi, Afshin ^{[6
]}

Rahighi, Saeed ^{[5
]}

Behravan, Javad ^{[1
,2
]}

机构：

[1] Sch Pharm, Dept Pharmacognosy & Biotechnol, Biotechnol Lab, Biotechnol Res Ctr, Mashhad, Iran

[2] Mashhad Univ Med Sci, Canc Res Ctr, Omid Hosp, Dept Biotechnol,Sch Pharm, Mashhad, Iran

[3] Mashhad Univ Med Sci, Canc Res Ctr, Omid Hosp, Dept Pathol, Mashhad, Iran

[4] Mashhad Univ Med Sci, Canc Res Ctr, Omid Hosp, Dept Radiat Oncol, Mashhad, Iran

[5] Azad Univ Mashhad, Dept Biochem, Sch Med, Mashhad, Iran

[6] Shaheed Beheshti Univ, Shohada Hosp, Sch Med, Tehran, Iran

来源：

CANCER INVESTIGATION | 2009年 / 27卷 / 08期

关键词：

Hypermethylation; Glioblastoma; O6-methylguanine-DNA methyltransferase; p53; DNA-REPAIR GENE; O-6-METHYLGUANINE-DNA METHYLTRANSFERASE; ALKYLATING-AGENTS; PREDICTS RESPONSE; G-C; CANCER; METHYLATION; INACTIVATION; TEMOZOLOMIDE; PATHWAYS;

D O I：

10.1080/07357900902783211

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

O6-methylguanine-DNA methyltransferase (MGMT) is a DNA repair enzyme that removes alkyl groups from the O6 position of guanine. MGMT is transcriptionally silenced by promoter hypermethylation in several human neoplasia. We used methylation-specific PCR (MSP) to analyze the MGMT promoter methylation status of 50 glioblastoma tumors. Hypermethylation was detected in 24 of 50 (48%) samples. We also analyzed mutant p53 expression by immunohistochemical analysis of glaioblastoma tissue samples. A significant association was found between MGMT methylation and p53 mutation status (p .05). These results suggested that epigenetic inactivation of MGMT plays an important role in the survival of glioblastoma patients and this inactivated gene involved in p53 mutation.

引用

页码：825 / 829

页数：5

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