Homeopathic ligand-free palladium as a catalyst in the Heck reaction. A comparison with a palladacycle

被引：523

作者：

de Vries, AHM ^{[1
]}

Mulders, JMCA ^{[1
]}

Mommers, JHM ^{[1
]}

Henderickx, HJW ^{[1
]}

de Vries, JG ^{[1
]}

机构：

[1] DSM Pharma Chem Adv Synth, Catalysis & Dev, NL-6160 MD Geleen, Netherlands

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 18期

关键词：

D O I：

10.1021/ol035184b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Ligand-free Pd(OAc)(2) can be used as a catalyst in the Heck reaction of aryl bromides as long as the amount of catalyst is kept between 0.01 and 0.1 mol %. At higher concentrations palladium black forms and the reaction stops. The actual catalyst is monomeric. Palladacycles merely serve as a source of ligand-free palladium in Heck reactions of aryl bromides.

引用

页码：3285 / 3288

页数：4

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