Design, synthesis, and evaluation of heparan sulfate mimicking glycopolymers for inhibiting heparanase activity

被引：37
|
作者：
Loka, Ravi S. [1 ]
Yu, Fei [1 ]
Sletten, Eric T. [1 ]
Nguyen, Hien M. [1 ]
机构：
[1] Univ Iowa, Dept Chem, Iowa City, IA 52242 USA
来源：
CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 65期
关键词：
TUMOR-GROWTH; ANGIOGENESIS; EXPRESSION; BINDING; AGGLUTINATION; PROTEOGLYCANS; METASTASIS; MIMETICS; RELEASE; CANCER;
D O I：
10.1039/c7cc04156j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Heparanase is an enzyme which cleaves heparan sulfate (HS) polysaccharides of the extracellular matrix. It is a regulator of tumor behavior, plays a key role in kidney related diseases and autoimmune diabetes. We report herein the use of computational studies to extract the natural HS-heparanase interactions as a template for the design of HS mimicking glycopolymers. Upon evaluation, a glycopolymer with 12 repeating units was determined to be the most potent inhibitor and to have tight-binding characteristics. This glycopolymer also lacks anticoagulant activity.
引用
收藏
页码：9163 / 9166
页数：4
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