A new type of cysteine proteinase inhibitor -: the salarin gene from Atlantic salmon (Salmo salar L.) and Arctic charr (Salvelinus alpinus)

被引：9
|
作者：
Olonen, A
Kalkkinen, N
Paulin, L
机构：
[1] Univ Helsinki, Inst Biotechnol, Prot Chem Lab, FIN-00014 Helsinki, Finland
[2] Univ Helsinki, Inst Biotechnol, DNA Synth & Sequencing Lab, FIN-00014 Helsinki, Finland
来源：
BIOCHIMIE | 2003年 / 85卷 / 07期
关键词：
cysteine proteinase inhibitor; Salmo salar; Salvelinus alpinus; salarin gene;
D O I：
10.1016/S0300-9084(03)00128-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Salarin is a 43 kDa glycoprotein which is found so far only in salmonid fish species. It is a strong inhibitor of cysteine proteinases. Here we characterised the salarin gene from Atlantic salmon and cDNA from Arctic charr. The salarin gene has 13 exons and 1026 bp long coding sequence. The translated amino acid sequence has four similar domains. The sequence resembles the proregion of cathepsins, known to inhibit cysteine proteinases. Salarin can be a new type of cysteine proteinase inhibitor. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码：677 / 681
页数：5
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