The Fanconi Anemia Pathway and Fertility

被引：79
|
作者：
Tsui, Vanessa [1 ,2 ]
Crismani, Wayne [1 ,2 ]
机构：
[1] St Vincents Inst Med Res, Genome Stabil Unit, Fitzroy, Vic 3065, Australia
[2] Univ Melbourne, Dept Med St Vincents Hlth, Melbourne, Vic 3010, Australia
来源：
TRENDS IN GENETICS | 2019年 / 35卷 / 03期
基金：
英国医学研究理事会;
关键词：
TARGETED DISRUPTION; MEIOTIC RECOMBINATION; DEFICIENT MICE; HOMOLOGOUS RECOMBINATION; CHROMOSOMAL INSTABILITY; HEMATOPOIETIC STEM; GENOME INSTABILITY; REDUCED FERTILITY; MOLECULAR-BIOLOGY; MALE-INFERTILITY;
D O I：
10.1016/j.tig.2018.12.007
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Fanconi anemia (FA) is a life-threatening syndrome characterized by bone marrow failure and cancer predispositions. The past two decades have seen an explosion of data in the FA field, both in humans and other organisms, following the cloning of 22 FA genes. A common but notably understudied clinical feature of the disease is the reduced fertility of individuals with FA. This review focuses on the known causes of reduced fertility in FA, and integrates them with the emerging role of the FA pathway in double-strand break (DSB) repair at meiosis in a variety of organisms, as well as providing future directions for research and diagnostics.
引用
收藏
页码：199 / 214
页数：16
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