Cell Fate Determination of Lymphatic Endothelial Cells

被引：6
|
作者：
Lee, Young Jae [1 ,2 ]
机构：
[1] Gachon Univ, Dept Biochem, Coll Med, Incheon 21999, South Korea
[2] Gachon Univ, Lee Gil Ya Canc & Diabet Inst, Incheon 21999, South Korea
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 13期
基金：
新加坡国家研究基金会;
关键词：
lymphangiogenesis; lymphatic vessels; lymphatic endothelial cells; cell fate; genetically modified mice; GROWTH-FACTOR RECEPTOR-3; MUTATIONS CAUSE NOONAN; OF-FUNCTION MUTATIONS; COUP-TFII; TRANSCRIPTION FACTOR; VASCULAR MORPHOGENESIS; NEGATIVE REGULATOR; PROX1; EXPRESSION; FACTOR-C; GENE;
D O I：
10.3390/ijms21134790
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The lymphatic vasculature, along with the blood vasculature, is a vascular system in our body that plays important functions in fluid homeostasis, dietary fat uptake, and immune responses. Defects in the lymphatic system are associated with various diseases such as lymphedema, atherosclerosis, fibrosis, obesity, and inflammation. The first step in lymphangiogenesis is determining the cell fate of lymphatic endothelial cells. Several genes involved in this commitment step have been identified using animal models, including genetically modified mice. This review provides an overview of these genes in the mammalian system and related human diseases.
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页码：1 / 14
页数：14
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