Relative contribution of free-virus and synaptic transmission to the spread of HIV-1 through target cell populations

被引：47
|
作者：
Komarova, Natalia L. [1 ,2 ]
Anghelina, Daniela [3 ]
Voznesensky, Igor [3 ]
Trinite, Benjamin [3 ]
Levy, David N. [3 ]
Wodarz, Dominik [1 ,2 ]
机构：
[1] Univ Calif Irvine, Dept Math, Irvine, CA 92697 USA
[2] Univ Calif Irvine, Dept Ecol & Evolut, Irvine, CA 92697 USA
[3] NYU, Coll Dent, Dept Basic Sci, New York, NY 10010 USA
来源：
BIOLOGY LETTERS | 2013年 / 9卷 / 01期
关键词：
human immunodeficiency virus; mathematical model; virological synapse; REPLICATION;
D O I：
10.1098/rsbl.2012.1049
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Human immunodeficiency virus can spread through target cells by transmission of cell-free virus or directly from cell-to-cell via formation of virological synapses. Although cell-to-cell transmission has been described as much more efficient than cell-free infection, the relative contribution of the two transmission pathways to virus growth during multiple rounds of replication remains poorly defined. Here, we fit a mathematical model to previously published and newly generated in vitro data, and determine that free-virus and synaptic transmission contribute approximately equally to the growth of the virus population.
引用
收藏
页数：6
相关论文
共 50 条
  • [41] Distribution of chemokine receptor CCR2 and CCR5 genotypes and their relative contribution to human immunodeficiency virus type 1 (HIV-1) seroconversion, early HIV-1 RNA concentration in plasma, and later disease progression
    Tang, JM
    Shelton, B
    Makhatadze, NJ
    Zhang, Y
    Schaen, M
    Louie, LG
    Goedert, JJ
    Seaberg, EC
    Margolick, JB
    Mellors, J
    Kaslow, RA
    JOURNAL OF VIROLOGY, 2002, 76 (02) : 662 - 672
  • [42] Inhibitory Effect of Individual or Combinations of Broadly Neutralizing Antibodies and Antiviral Reagents against Cell-Free and Cell-to-Cell HIV-1 Transmission
    Gombos, Randi B.
    Kolodkin-Gal, Dror
    Eslamizar, Leila
    Owuor, Joshua O.
    Mazzola, Emanuele
    Gonzalez, Ana M.
    Korioth-Schmitz, Birgit
    Gelman, Rebecca S.
    Montefiori, David C.
    Haynes, Barton F.
    Schmitz, Joern E.
    JOURNAL OF VIROLOGY, 2015, 89 (15) : 7813 - 7828
  • [43] PVP-coated silver nanoparticles block the transmission of cell-free and cell-associated HIV-1 in human cervical culture
    Lara H.H.
    Ixtepan-Turrent L.
    Garza-Treviño E.N.
    Rodriguez-Padilla C.
    Journal of Nanobiotechnology, 8 (1)
  • [44] Sugar transport and glut transporter expression in a variety of human immunodeficiency virus-1 (HIV-1) chronically infected target cell lines
    Caro, C
    Colby-Germinario, S
    Brenner, B
    Olveira, M
    Wainberg, MA
    Germinario, RJ
    INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 1998, 30 (09): : 1031 - 1038
  • [45] Assessment of oral transmission using cell-free HIV-1 in mouse models reconstituted with human peripheral blood leukocytes.
    Nakao, R.
    Amagasa, T.
    Aoba, T.
    Hanada, N.
    Senpuku, H.
    JOURNAL OF DENTAL RESEARCH, 2003, 82 : B220 - B220
  • [46] The Envelope Cytoplasmic Tail of HIV-1 Subtype C Contributes to Poor Replication Capacity through Low Viral Infectivity and Cell-to-Cell Transmission
    da Silva, Eveline Santos
    Mulinge, Martin
    Lemaire, Morgane
    Masquelier, Cecile
    Beraud, Cyprien
    Rybicki, Arkadiusz
    Servais, Jean-Yves
    Iserentant, Gilles
    Schmit, Jean-Claude
    Seguin-Devaux, Carole
    Bercoff, Danielle Perez
    PLOS ONE, 2016, 11 (09):
  • [47] Inhibition of virus attachment to CD4(+) target cells is a major mechanism of T cell line-adapted HIV-1 neutralization
    Ugolini, S
    Mondor, I
    Parren, PWHI
    Burton, DR
    Tilley, SA
    Klasse, PJ
    Sattentau, QJ
    JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (08): : 1287 - 1298
  • [48] Synthetic immunotherapy induces HIV virus specific Th1 cytotoxic response and death of an HIV-1 infected human cell line through classic complement activation
    Pleguezuelos, Olga
    Stoloff, Gregory A.
    Caparros-Wanderley, Wilson
    VIROLOGY JOURNAL, 2013, 10
  • [49] Synthetic immunotherapy induces HIV virus specific Th1 cytotoxic response and death of an HIV-1 infected human cell line through classic complement activation
    Olga Pleguezuelos
    Gregory A Stoloff
    Wilson Caparrós-Wanderley
    Virology Journal, 10
  • [50] Human T-Cell Lymphotropic Virus in Patients Infected with HIV-1: Molecular Epidemiology and Risk Factors for Transmission in Piaui, Northeastern Brazil
    de Oliveira, Evaldo H.
    Oliveira-Filho, Aldemir B.
    Souza, Lucinda A.
    da Silva, Letiano V.
    Ishak, Marlusa O. G.
    Ishak, Ricardo
    Vallinoto, Antonio C. R.
    CURRENT HIV RESEARCH, 2012, 10 (08) : 700 - 707
12345