A Gelatin-Based Hydrogel with β-Cyclodextrin Crosslinker for Controlled Drug Release

被引：0

作者：

Liu, C. D. ^{[1
]}

Zhang, Z. X. ^{[2
]}

Chan, V. M. H. ^{[1
]}

Tan, M. J. ^{[1
]}

Liu, X. ^{[1
]}

Li, J. ^{[1
,2
]}

机构：

[1] Natl Univ Singapore, Fac Engn, Div Bioengn, 9 Engn Dr 1, Singapore 117576, Singapore

[2] Natl Univ Singapore, Inst Mat Res Engn, Singapore 117602, Singapore

来源：

5TH EUROPEAN CONFERENCE OF THE INTERNATIONAL FEDERATION FOR MEDICAL AND BIOLOGICAL ENGINEERING, PTS 1 AND 2 | 2012年 / 37卷

关键词：

Gelatin hydrogel; beta-cyclodextrin crosslinker; Inclusion complex; Controlled drug release; Methotrexate (MTX); DELIVERY;

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A novel gelatin hydrogel was prepared by using 1, 1'-carbonyldiimidazole (CM) activated beta-cyclodextrin (beta-CD) as crosslinker. The hydrogel was characterized by H NMR spectroscopy, in vitro degradation, MTT assay, drug loading/release study with anticancer drug of methotrexate (MTX). Degradation and drug loading/release properties of the hydrogel can be controlled by changing the crosslinker content. In vitro cytotoxicity test indicated nontoxicity of this material to L929 cells (mouse connective tissue fibroblast), showing that this new crosslinked gelatin hydrogel is biocompatible and can be used as a potential drug carrier in human body.

引用

页码：1090 / +

页数：2

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