Vanishing Bile Duct Syndrome and Hodgkin Disease A Case Series and Review of the Literature

被引：16

作者：

Pass, Amy Kun ^{[1
,2
]}

McLin, Valerie A. ^{[1
,2
]}

Ruston, Jennifer R. ^{[1
,2
]}

Kearney, Debra L. ^{[1
,2
]}

Hastings, Caroline A. ^{[3
]}

Margolin, Judith F. ^{[1
,2
]}

机构：

[1] Texas Childrens Hosp, Houston, TX 77030 USA

[2] Baylor Coll Med, Houston, TX 77030 USA

[3] Childrens Hosp & Res Ctr, Dept Pediat Hematol Oncol, Oakland, CA USA

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2008年 / 30卷 / 12期

关键词：

Hodgkin disease; vanishing bile duct syndrome; cholestasis; hepatotoxicity;

D O I：

10.1097/MPH.0b013e31818b37c4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This is the first description in which the diagnosis of vanishing bile duct syndrome (VBDS) preceded the diagnosis of Hodgkin disease (HD) by several months, and for which patients received modifications to modern MOPP-ABV chemotherapy with successful clinical remission. VBDS is an uncommon form of liver disease manifested by severe cholestasis and progressive liver failure. We report 2 cases of stage IIIB pediatric HD and VBDS. Because VBDS is progressive and the only curative treatment is liver transplant, it is imperative to recognize that children with VBDS may also have concurrent H D.

引用

页码：976 / 980

页数：5

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