INVESTIGATION OF THE CONFORMATIONAL TRANSFORMATIONS IN SOME 7α-METHYL6-OXA-14β-ANALOGS OF STEROIDAL ESTROGENS BY NMR SPECTROSCOPY

被引：2
|
作者：
Selivanov, S. I. [1 ]
Morozkina, S. N. [1 ]
Chentsova, A. S. [1 ]
Shavva, A. G. [1 ]
机构：
[1] St Petersburg State Univ, Fac Chem, St Petersburg 198504, Russia
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2008年 / 44卷 / 06期
关键词：
6-oxa-14 beta-analogs of steroidal estrogens; conformational equilibria; NMR spectroscopy;
D O I：
10.1007/s10593-008-0091-8
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The stereochemical structure and conformational transformations of two 6-oxa-14 beta-estra-1,3,5(10), 8(9)-tetraenes having an alpha-methyl group at position 7 were investigated. It was found that the substituent at the C-17 atom has an effect on the formation of the conformers in solution. In the analog containing a C-17 keto group in solution there are two conformers, whereas the 17 alpha-acetoxy derivative has only one conformer.
引用
收藏
页码：654 / 665
页数：12
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