The biologic concept for the use of enamel matrix protein: True periodontal regeneration

Guided tissue regeneration procedures have been used successfully to reestablish periodontal attachment. However this new attachment reportedly differs from the original attachment in sti strength and continuity. Enamel matrix proteins secreted by Hertwig's epithelial sheath play art important role in cementogenesis on roots and in the development of the periodontal attachment apparatus. Enamel matrix protein harvested from developing pot-cine teeth, or enamel matrix derivative (Emdogain), is reported to induce true periodontal regeneration (the attachment of new, acellular cementum to the underlying dentin surface). The results of experimental and clinical trials of Emdogain are reviewed, and the procedure for application of the material is described.