The impact of anemia on quality of life and hospitalisation in elderly cancer patients undergoing chemotherapy

Aim of the study: At present, there is very little data available about the impact of anemia on elderly cancer patient's quality of life (QoL). Most of the acquired knowledge has been derived from small studies selected for primary site cancer. This observational study investigates the association between hemoglobin (Hb) level and comprehensive geriatric assessment variables: Cancer Linear Analog Scale (CLAS), Activities of Daily Living (ADL), Mini-Mental State Examination (MMSE) in elderly cancer patients undergoing chemotherapy (CT). Methods: We enrolled 586 elderly cancer patients undergoing CT who were evaluated at baseline and every 3-4 weeks for at least 12 weeks. The correlation between Hb level changes and the examined index changes were performed using Pearson correlation analysis and a multivariate analysis was performed using a logistic regression model. Results: Both univariate and multivariate analyses at baseline showed that Hb values are related to ECOG performance status (PS), stage of disease and self-reported QoL. Hb level variation significantly correlated with CLAS and ADL changes measured at baseline and after 12 weeks. This correlation is highly significant in patients with Hb < 11 g/dl. Multivariate analysis showed that Hb change of at least 1 g/dl was the only independent predictor of a better quality of life, when assessed by using the CLAS and ADL questionnaire (p < 0.05). Moreover the median time of hospitalisation was found to be significantly lower in patients showing higher Hb level (Hb >= 11 g/dl) (p = 0.037). Conclusions: The findings of this study seem to provide adequate support for the correlation between anemia and elderly cancer patient's QoL. Interestingly, we reported an association between anemia and the length of hospitalisation in this setting of patients. However, the above results do need to be confirmed by further prospective trials. (C) 2010 Elsevier Ireland Ltd. All rights reserved.