Biomolecular structure and dynamics - Experiment and theory

Biological macromolecules are complex systems and in order to understand their inner workings we need information from many sources. In this review we present some of the underlying principles for current methods of choice for structural and dynamical studies of biological macromolecules. Interplay between these disciplines-X-ray diffraction,;nuclear magnetic resonance spectroscopy and theoretical calculations-has been extremely fruitful and our knowledge in this area of bioscience is rapidly increasing due to this cross-fertilization. While structural aspects of proteins; are increasingly well studied and understood we do however still need to put more emphasis on their dynamical properties.