Febrile Neutropenia in a Metastatic Melanoma Patient Treated with Ipilimumab - Case Report

被引：18
|
作者：
Wozniak, Sebastian [1 ]
Mackiewicz-Wysocka, Malgorzata [2 ]
Krokowicz, Lukasz [3 ]
Kwinta, Lukasz [1 ]
Mackiewicz, Jacek [4 ,5 ,6 ]
机构：
[1] Greater Poland Canc Ctr, Dept Chemotherapy, Poznan, Poland
[2] Poznan Univ Med Sci, Dept Dermatol, Poznan, Poland
[3] Univ Med Sci, Dept Gen Endocrinol & Gastroenterol Oncol Surg, Poznan, Poland
[4] Univ Med Sci, Med Biotechnol, PL-61051 Poznan, Poland
[5] Greater Poland Canc Ctr, Dept Diagnost & Canc Immunol, Poznan, Poland
[6] Malgorzata Med Ctr, Dept Med Oncol, Srem, Poland
来源：
ONCOLOGY RESEARCH AND TREATMENT | 2015年 / 38卷 / 03期
关键词：
Ipilimunnab; Anti-CTLA4; Immunotherapy; Melanoma; EFFICACY;
D O I：
10.1159/000377650
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: lpilimumab is a fully human monoclonal antibody (mAb) targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4). lpilimumab is currently approved in the U.S. and Europe for the treatment of metastatic melanoma in the first- and second-line treatment. Treatment with ipilinnumab is linked to immune-related adverse events (irAEs) occurring in the majority of patients. These specific AEs include dermatitis, gastrointestinal disorders (diarrhea, colitis), hepatitis, hypophysitis, hypothyroidism, neuropathy, and iritis/inflammation of the ciliary body. Case Report: We report a case of febrile neutropenia with agranulocytosis in the blood smear of a 35-year-old metastatic melanoma patient treated with ipilimumab 3 mg/kg. Conclusion: This AE was probably caused by antineutrophil antibodies associated with ipilimumab treatment. To our knowledge this is the first case report of febrile neutropenia in a metastatic melanoma patient treated with ipilimumab 3 mg/kg.
引用
收藏
页码：105 / 108
页数：4
相关论文
共 50 条
  • [21] Febrile neutropenia in a patient with non-small-cell lung cancer treated with atezolizumab: A case report
    Seguchi, Kyosuke
    Nakashima, Kei
    Terao, Toshiki
    Takeshita, Gaku
    Nagai, Tatsuya
    Tanaka, Yu
    [J]. RESPIRATORY MEDICINE CASE REPORTS, 2021, 33
  • [22] Severe febrile neutropenia and pancytopenia in a patient with advanced hepatocellular carcinoma treated with atezolizumab and bevacizumab: a case report
    Chamseddine, Shadi
    LaPelusa, Michael
    Carter, Kristen
    Nguyen, Van
    Mohamed, Yehia I.
    Sakr, Yara
    Rojas-Hernandez, Cristhiam M.
    Hatia, Rikita I.
    Hassan, Manal
    Goss, John A.
    Elsayes, Khaled M.
    Rashid, Asif
    Sun, Ryan
    Cao, Hop Sanderson Tran
    Amin, Hesham M.
    Kaseb, Ahmed O.
    [J]. JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2024, 15 (03) : 1324 - 1330
  • [23] Serial pseudoprogression of metastatic malignant melanoma in a patient treated with nivolumab: a case report
    Ozaki, Yukinori
    Shindoh, Junichi
    Miura, Yuji
    Nakajima, Hiromichi
    Oki, Ryosuke
    Uchiyama, Miyuki
    Masuda, Jun
    Kinowaki, Keiichi
    Kondoh, Chihiro
    Tanabe, Yuko
    Tanaka, Tsuyoshi
    Haruta, Shusuke
    Ueno, Masaki
    Kitano, Shigehisa
    Fujii, Takeshi
    Udagawa, Harushi
    Takano, Toshimi
    [J]. BMC CANCER, 2017, 17
  • [24] Serial pseudoprogression of metastatic malignant melanoma in a patient treated with nivolumab: a case report
    Yukinori Ozaki
    Junichi Shindoh
    Yuji Miura
    Hiromichi Nakajima
    Ryosuke Oki
    Miyuki Uchiyama
    Jun Masuda
    Keiichi Kinowaki
    Chihiro Kondoh
    Yuko Tanabe
    Tsuyoshi Tanaka
    Shusuke Haruta
    Masaki Ueno
    Shigehisa Kitano
    Takeshi Fujii
    Harushi Udagawa
    Toshimi Takano
    [J]. BMC Cancer, 17
  • [25] Occurrence of Fatal Tubulopathy in an Old, Fit Patient Receiving Nivolumab and Ipilimumab for Metastatic Melanoma: A Case Report
    Georgery, Marine
    Ram, Aurelie
    Van Meerhaeghe, Tess
    Drowart, Annie
    Clause, Anne-Lorraine
    Dal Lago, Lissandra
    Rouviere, Heloise
    [J]. CASE REPORTS IN ONCOLOGY, 2024, 17 (01): : 239 - 246
  • [26] Bariatric surgery in a patient treated with targeted therapies for metastatic melanoma: a case report
    Velter, Charles
    Sakkal, Madona
    Robert, Caroline
    [J]. MELANOMA RESEARCH, 2020, 30 (06) : 629 - 630
  • [27] Repeated Treatment Response of metastatic malignant Melanoma to Ipilimumab in a Patient with chronic lymphatic Leukaemie - a Case Report
    Mueller-Brenne, T.
    Hurlbeck, S.
    Wilden, S.
    Grabbe, S.
    Loquai, C.
    [J]. JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, 2014, 12 : 33 - 33
  • [28] A case of dual-mechanism immune-related anaemia in a patient with metastatic melanoma treated with nivolumab and ipilimumab
    Olson, Daniel J.
    Rajagopal, Padma
    Tjota, Melissa Y.
    Venkataraman, Girish
    Luke, Jason J.
    Gajewski, Thomas F.
    [J]. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 8 (01)
  • [29] Case Report of metastatic Melanoma Mucosa with partial Response to Ipilimumab and Pembrolizumab
    Mauer, K.
    Jaeger, E.
    Pinter, A.
    Kaufmann, R.
    Meissner, M.
    [J]. JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, 2015, 13 : 41 - 42
  • [30] Cancer duplicity: a case of chronic lymphocytic leukemia and metastatic melanoma treated with Ipilimumab
    Spallone, Giulia
    Ventura, Alessandra
    Mazzeo, Mauro
    Di Raimondo, Cosimo
    Lombardo, Paolo
    Silvaggio, Dionisio
    Bianchi, Luca
    [J]. ITALIAN JOURNAL OF DERMATOLOGY AND VENEREOLOGY, 2021, 156 (01) : 112 - 113
12345