Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice

被引:27
|
作者
Li, Xing [1 ]
Matsumoto, Tomohiro [1 ]
Takuwa, Miho [1 ]
Saeed Ebrahim Shaiku Ali, Mahmood [1 ]
Hirabashi, Takumi [1 ]
Kondo, Hiroyo [1 ]
Fujino, Hidemi [1 ]
机构
[1] Kobe Univ, Grad Sch Hlth Sci, Dept Rehabil Sci, 7-10-2 Tomogaoka, Kobe, Hyogo 6540142, Japan
关键词
astaxanthin; antioxidant; skin; ultraviolet; photoaging; capillary; ATROPHIED SOLEUS MUSCLE; OXIDATIVE STRESS; SKELETAL-MUSCLE; SKIN; DAMAGE; EXPRESSION; GENERATION; REGRESSION; RADIATION; BENEFITS;
D O I
10.3390/biomedicines8020018
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Ultraviolet (UV) light induces skin photoaging, which is characterized by thickening, wrinkling, pigmentation, and dryness. Astaxanthin (AST), a ketocarotenoid isolated from Haematococcus pluvialis, has been extensively studied owing to its possible effects on skin health as well as UV protection. In addition, AST attenuates the increased generation of reactive oxygen species (ROS) and capillary regression of the skeletal muscle. In this study, we investigated whether AST could protect against UV-induced photoaging and reduce capillary regression in the skin of HR-1 hairless mice. UV light induces wrinkle formation, epidermal thickening, and capillary regression in the dermis of HR-1 hairless mice. The administration of AST reduced the UV-induced wrinkle formation and skin thickening, and increased collagen fibers in the skin. AST supplementation also inhibited the generation of ROS, decreased wrinkle formation, reduced epidermal thickening, and increased the density of capillaries in the skin. We also found an inverse correlation between wrinkle formation and the density of capillaries. An association between photoaging and capillary regression in the skin was also observed. These results suggest that AST can protect against photoaging caused by UV irradiation and the inhibitory effects of AST on photoaging may be associated with the reduction of capillary regression in the skin.
引用
收藏
页数:14
相关论文
共 50 条
  • [21] Leptin alleviates ultraviolet-induced skin photoaging in human skin fibroblasts and mice
    Zhou, Zhi-Qiang
    Sui, Zhi-Fu
    Tian, Yan-Li
    Zhao, Zhi-Li
    Shi, Cheng-Fang
    Liu, Chang
    Yang, Rong-Ya
    [J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2016, 9 (02): : 1084 - 1094
  • [22] Reply: Protective Effects of Micronized Fat against Ultraviolet B-Induced Photoaging
    He, Anqi
    Wang, Lu
    Wang, Qiang
    Luan, Wenjie
    Qi, Fazhi
    [J]. PLASTIC AND RECONSTRUCTIVE SURGERY, 2021, 147 (04) : 696E - 697E
  • [23] Red Light Modulates Ultraviolet-Induced Gene Expression in the Epidermis of Hairless Mice
    Myakishev-Rempel, Max
    Stadler, Istvan
    Polesskaya, Oksana
    Motiwala, Alifiya S.
    Nardia, Frances Barg
    Mintz, Benjamin
    Baranova, Ancha
    Zavislan, James
    Lanzafame, Raymond J.
    [J]. PHOTOMEDICINE AND LASER SURGERY, 2015, 33 (10) : 498 - 503
  • [24] THE PROTECTIVE EFFECT OF CHLOROQUINE AGAINST ULTRAVIOLET-INDUCED BIOCHEMICAL CHANGES
    OGURA, R
    KNOX, JM
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1964, 42 (06) : 461 - 464
  • [25] Protective effects of topical application of a poorly soluble antioxidant astaxanthin liposomal formulation on ultraviolet-induced skin damage
    Hama, Susumu
    Takahashi, Kanako
    Inai, Yuko
    Shiota, Kanako
    Sakamoto, Ryota
    Yamada, Asako
    Tsuchiya, Hiroyuki
    Kanamura, Kiyoshi
    Yamashita, Eiji
    Kogure, Kentaro
    [J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 2012, 101 (08) : 2909 - 2916
  • [26] Protective effects of a Kampo prescription, hochuekkito, against ultraviolet B-induced oxidative stress in hairless mice skin
    Kobayashi, Hiromi
    Yanagihara, Shigeto
    Tamiya, Hisashi
    Tsuruta, Daisuke
    Nakanishi, Takeshi
    Mizuno, Nobuyuki
    Hiramoto, Keiichi
    Okano, Yuri
    Ishii, Masamitsu
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2011, 131 : S58 - S58
  • [27] Anti-Inflammatory and Photoprotective Effects of Magnetic Nanoparticles Against Ultraviolet-Induced Photoaging in Human Skin Cells
    Lee, Jeong Min
    Shin, Jae-Soo
    Lee, Kwon-Jai
    An, Jeung Hee
    [J]. SCIENCE OF ADVANCED MATERIALS, 2014, 6 (11) : 2501 - 2504
  • [28] Protective effects of astaxanthin against ischemia/reperfusion induced renal injury in mice
    Xuefeng Qiu
    Kai Fu
    Xiaozhi Zhao
    Yanting Zhang
    Yimin Yuan
    Shiwei Zhang
    Xiaoping Gu
    Hongqian Guo
    [J]. Journal of Translational Medicine, 13
  • [29] Protective effects of astaxanthin against ischemia/reperfusion induced renal injury in mice
    Qiu, Xuefeng
    Fu, Kai
    Zhao, Xiaozhi
    Zhang, Yanting
    Yuan, Yimin
    Zhang, Shiwei
    Gu, Xiaoping
    Guo, Hongqian
    [J]. JOURNAL OF TRANSLATIONAL MEDICINE, 2015, 13
  • [30] Effects of fish collagen on hairless mice skin photoaging induced by ultraviolet irradiation via regulation of the TGF- β signaling pathway Anti-photoaging effect of fish collagen in UVB-induced hairless mice
    Song, Hee Ho
    Hong, Ki-Bae
    Kim, Sunhoo
    Kim, Byung-Yong
    Shik, Shin Hyung
    Suh, Hyung Joo
    Ahn, Yejin
    [J]. JOURNAL OF FUNCTIONAL FOODS, 2023, 105