Application of Kelvin force microscopy for evaluation of oxidized low-density lipoprotein

被引：0

作者：

Takeda, Seiji ^{[1
]}

Ohkawa, Futaba ^{[1
]}

Sakurai, Toshihiro ^{[1
]}

Jin, Shigeki ^{[1
]}

Fuda, Hirotoshi ^{[1
]}

Hui, Shu-Ping ^{[1
]}

Chiba, Hitoshi ^{[1
]}

Sueoka, Kazuhisa ^{[2
]}

机构：

[1] Hokkaido Univ, Fac Hlth Sci, Sapporo, Hokkaido, Japan

[2] Hokkaido Univ, Grad Sch Informat Sci & Technol, Sapporo, Hokkaido, Japan

来源：

2012 IEEE SENSORS PROCEEDINGS | 2012年

关键词：

D O I：

暂无

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Investigation of the properties of oxidized low-density lipoprotein is important because it is a risk factor of cardiovascular disease development. Low-density lipoprotein is known to have a positive charge on the surface attributable to amino groups of lysine moieties. Its positive charge can be decreased by oxidation. For this study, the topography and surface potential of LDL and ox-LDL were measured using atomic force microscopy and Kelvin probe force microscopy. The Kelvin probe force microscopy images of ox-LDL differ from those obtained using n-LDL. We demonstrated a method to evaluate the oxidation level of LDL using AFM and KPFM.

引用

页码：1751 / 1754

页数：4

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