Direct effects of transforming growth factor-β1 signaling on the differentiation fate of fetal hepatic progenitor cells

被引：0
|
作者：
Yasen, Aimaiti [1 ,2 ]
Li, Wending [1 ]
Maimaitinijiati, Yusufukadier [1 ]
Aini, Abudusalamu [1 ]
Ran, Bo [2 ]
Wang, Hui [3 ]
Tuxun, Tuerhongjiang [4 ]
Shao, Yingmei [2 ]
Aji, Tuerganaili [2 ]
Wen, Hao [2 ,5 ]
机构：
[1] Xinjiang Med Univ, Xinjiang Uyghur Autonomous Reg, Urumqi 830011, Peoples R China
[2] Xinjiang Med Univ, Digest & Vasc Surg Ctr, Dept Hepatobiliary & Hydatid Dis, Affiliated Hosp 1, Urumqi 830054, Peoples R China
[3] Xinjiang Med Univ, Clin Med Res Inst, Affiliated Hosp 1, Urumqi 830054, Xinjiang Uyghur, Peoples R China
[4] Xinjiang Med Univ, Digest & Vasc Surg Ctr, Dept Liver & Laparoscop Surg, Affiliated Hosp 1, Urumqi 830054, Xinjiang Uyghur, Peoples R China
[5] Xinjiang Med Univ, State Key Lab Pathogenesis Prevent & Treatment Hi, 393 Xin Yi Rd, Urumqi 830011, Xinjiang Uyghur, Peoples R China
来源：
REGENERATIVE MEDICINE | 2020年 / 15卷 / 06期
关键词：
development; differentiation; fetal hepatic progenitor cells; fetal liver; TGF-beta; 1; HEPATOCYTE TRANSPLANTATION; MOUSE-LIVER; EXPRESSION; HEPATOBLASTS; REPOPULATION; MATURATION; CULTURE; DEVELOP; JAGGED1; SERUM;
D O I：
10.2217/rme-2020-0002
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Aim:To investigate direct roles of TGF-beta 1 signaling in the differentiation process of fetal hepatic progenitor cells (HPCs).Materials & methods:Exogenous TGF-beta 1 and SB431542 were added into fetal HPCs. Then, SB431542 was intraperitoneally injected into pregnant mice for 8 days.Results:Fetal HPCs treated with TGF-beta 1 differentiated into cholangiocytes. However, hepatocyte marker was highly expressed after inhibiting TGF-beta 1 signaling.In vivo, hematopoietic cells were gradually replaced with liver cells and TGF-beta 1 expression was evidently decreased as fetal liver developed. Inhibition of TGF-beta 1 signaling caused increase of ALB(+)cells, but CK19 expression was more obvious in control mice livers.Conclusion:TGF-beta 1 signaling may play decisive roles in fetal HPCs differentiation into functional hepatocytes or cholangiocytes.
引用
收藏
页码：1719 / 1733
页数：15
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