Anti-mitochondrial antibodies and other immunological tests in primary biliary cirrhosis

被引：18
|
作者：
Strassburg, CP [1 ]
Jaeckel, E [1 ]
Manns, MP [1 ]
机构：
[1] Hannover Med Sch, Dept Gastroenterol & Hepatol, D-30625 Hannover, Germany
来源：
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | 1999年 / 11卷 / 06期
关键词：
antimitochondrial antibodies; antinuclear antibodies; autoimmunity; cholestasis; primary biliary cirrhosis; pyruvate dehydrogenase;
D O I：
10.1097/00042737-199906000-00003
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Primary biliary cirrhosis (PBC) has been classified as an autoimmune disease, It is characterized by a multitude of immune-mediated symptoms and phenomena. Humoral autoimmunity directed against mitochondrial autoantigens or structures cross-reactive with these proteins represents the basis of one of the most specific tests in any autoimmune disease: the detection of auto-antibodies against pyruvate dehydrogenase. The molecular cloning and expression of antigens of the ketoacid dehydrogenase complex has led to the establishment of highly specific and reliable testing systems for anti-mitochondrial antibodies (AMA). The characterization of specific antinuclear auto-antibodies has contributed to the diagnosis of AMA-negative PBC and is an important marker in overlap syndromes of PBC and other autoimmune liver diseases, Eur J Gastroenterol Hepatol 11:595-601. (C) 1999 Lippincott Williams & Wilkins.
引用
收藏
页码：595 / 601
页数：7
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