Genomics in Clinical Practice: Lessons from the Front Lines

被引：71

作者：

Jacob, Howard J. ^{[1
,5
,6
]}

Abrams, Kelly ^{[12
]}

Bick, David P. ^{[1
,5
,10
]}

Brodie, Kent ^{[1
]}

Dimmock, David P. ^{[1
,5
,10
]}

Farrell, Michael ^{[3
]}

Geurts, Jennifer ^{[1
,7
]}

Harris, Jeremy ^{[1
,5
]}

Helbling, Daniel ^{[1
,5
]}

Joers, Barbara J. ^{[12
]}

Kliegman, Robert ^{[5
]}

Kowalski, George ^{[1
]}

Lazar, Jozef ^{[1
,2
]}

Margolis, David A. ^{[5
]}

North, Paula ^{[4
,9
,11
]}

Northup, Jill ^{[1
]}

Roquemore-Goins, Altheia ^{[11
]}

Scharer, Gunter ^{[1
,5
,10
]}

Shimoyama, Mary ^{[1
,7
]}

Strong, Kimberly ^{[1
,8
]}

Taylor, Bradley ^{[1
]}

Tsaih, Shirng-Wern ^{[1
]}

Tschannen, Michael R. ^{[1
]}

Veith, Regan L. ^{[1
,10
]}

Wendt-Andrae, Jaime ^{[1
]}

Wilk, Brandon ^{[1
,5
]}

Worthey, Elizabeth A. ^{[1
,5
,9
]}

机构：

[1] Med Coll Wisconsin, Human & Mol Genet Ctr, Milwaukee, WI 53226 USA

[2] Med Coll Wisconsin, Dept Dermatol, Milwaukee, WI 53226 USA

[3] Med Coll Wisconsin, Dept Med, Milwaukee, WI 53226 USA

[4] Med Coll Wisconsin, Dept Pathol, Milwaukee, WI 53226 USA

[5] Med Coll Wisconsin, Dept Pediat, Milwaukee, WI 53226 USA

[6] Med Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA

[7] Med Coll Wisconsin, Dept Surg, Milwaukee, WI 53226 USA

[8] Med Coll Wisconsin, Inst Hlth & Soc, Milwaukee, WI 53226 USA

[9] Med Coll Wisconsin, Childrens Res Inst, Milwaukee, WI 53226 USA

[10] Med Coll Wisconsin, Genom Med Clin, Milwaukee, WI 53226 USA

[11] Med Coll Wisconsin, Clin Lab, Milwaukee, WI 53226 USA

[12] Childrens Hosp Wisconsin, Milwaukee, WI 53226 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2013年 / 5卷 / 194期

关键词：

INCIDENTAL FINDINGS;

D O I：

10.1126/scitranslmed.3006468

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The price of whole-genome and -exome sequencing has fallen to the point where these methods can be applied to clinical medicine. Here, we outline the lessons we have learned in converting a sequencing laboratory designed for research into a fully functional clinical program.

引用

页数：5

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