Clonal haematopoiesis and atherosclerosis: a chicken or egg question?

被引：14
|
作者：
Sanchez-Cabo, Fatima [1 ]
Fuster, Jose J. [1 ]
机构：
[1] Ctr Nacl Invest Cardiovasc CNIC, Madrid, Spain
来源：
NATURE REVIEWS CARDIOLOGY | 2021年 / 18卷 / 07期
关键词：
HEART-FAILURE; RISK;
D O I：
10.1038/s41569-021-00554-z
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Sequencing studies demonstrate a strong clinical association between clonal haematopoiesis driven by acquired mutations and atherosclerotic disease. Previous research supports the idea that this association reflects a direct contribution of some clonal haematopoiesis-related mutations to atherosclerosis. Now, mathematical modelling suggests that atherosclerosis could instead accelerate clonal haematopoiesis.
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页码：463 / 464
页数：2
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