Molecular and Cellular Mechanisms Involved in Mesenchymal Stem Cell-Based Therapy of Inflammatory Bowel Diseases

被引：41

作者：

Markovic, Bojana Simovic ^{[1
]}

Kanjevac, Tatjana ^{[2
]}

Harrell, C. Randall ^{[3
]}

Gazdic, Marina ^{[4
]}

Fellabaum, Crissy ^{[3
]}

Arsenijevic, Nebojsa ^{[1
]}

Volarevic, Vladislav ^{[1
]}

机构：

[1] Univ Kragujevac, Ctr Mol Med & Stem Cell Res, Dept Microbiol & Immunol, Fac Med Sci, 69 Svetozar Markovic St, Kragujevac 34000, Serbia

[2] Univ Kragujevac, Dept Dent, Fac Med Sci, 69 Svetozar Markovic St, Kragujevac 34000, Serbia

[3] Regenerat Proc Plant LLC, 34176 US Highway 19 N Palm Harbor, Palm Harbor, FL USA

[4] Univ Kragujevac, Dept Genet, Fac Med Sci, Kragujevac, Serbia

来源：

STEM CELL REVIEWS AND REPORTS | 2018年 / 14卷 / 02期

关键词：

Mesenchymal stem cells; Chron's disease; Ulcerative colitis; Transplantation; Cell-based therapy; UMBILICAL-CORD BLOOD; REGULATORY T-CELLS; REFRACTORY CROHNS-DISEASE; COMPLEX PERIANAL FISTULA; SODIUM-INDUCED COLITIS; BONE-MARROW; STROMAL CELLS; ADIPOSE-TISSUE; INTERFERON-GAMMA; DENDRITIC CELLS;

D O I：

10.1007/s12015-017-9789-2

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Mesenchymal stem cells (MSCs) are promising resource for the therapy of inflammatory bowel diseases (IBDs) on the grounds of their differentiation capabilities and immuno-modulatory characteristics. Results of clinical studies indicate that local application of MSCs is a secure and beneficial approach for the treatment of perianal fistulas while systemic application of MSCs leads to the attenuation or aggravation of IBDs. Herein, we emphasized molecular mechanisms and approaches that should improve efficacy of MSC-based therapy of IBDs.

引用

页码：153 / 165

页数：13

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