Effects of probiotic supplements on cognition, anxiety, and physical activity in subjects with mild and moderate Alzheimer's disease: A randomized, double-blind, and placebo-controlled study
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作者:
Akhgarjand, Camellia
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Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Tehran, IranUniv Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Tehran, Iran
Akhgarjand, Camellia
[1
]
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Vahabi, Zahra
[2
,3
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Shab-Bidar, Sakineh
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Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, IranUniv Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Tehran, Iran
Shab-Bidar, Sakineh
[4
]
Etesam, Farnaz
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Univ Tehran Med Sci, Sina MS Res Ctr, Brain & Spinal Injury Res Ctr, Tehran, IranUniv Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Tehran, Iran
Etesam, Farnaz
[5
]
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Djafarian, Kurosh
[1
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机构:
[1] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Tehran, Iran
[2] Univ Tehran Med Sci, Roozbeh Hosp, Dept Psychiat, Cognit Neurol & Neuropsychiat Div, Tehran, Iran
[3] Univ Tehran Med Sci, Ziaeeian Hosp, Dept Geriatr, Tehran, Iran
[4] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran
[5] Univ Tehran Med Sci, Sina MS Res Ctr, Brain & Spinal Injury Res Ctr, Tehran, Iran
Probiotics have been suggested as an effective adjuvant treatment for Alzheimer's disease (AD) due to their modulating effect on the gut microbiota, which may affect the gut-brain axis. Therefore, we aimed to evaluate the effects of two different single-strain probiotics on cognition, physical activity, and anxiety in subjects with mild and moderate AD. Eligible patients (n = 90) with AD were randomly assigned to either of two interventions [Lactobacillus rhamnosus HA-114 (10(15) CFU) or Bifidobacterium longum R0175 (10(15) CFU)] or placebo group, receiving probiotic supplement twice daily for 12 weeks. The primary outcome of the study was cognitive function measured by using the two tests, namely, the Mini-Mental State Examination (MMSE) and the categorical verbal fluency test (CFT). Secondary outcomes included a performance in Activities of Daily Living (ADL), the Lawton Instrumental Activities of Daily Living (IADL) scale, and the Generalized Anxiety Disorder (GAD-7) scale. Linear mixed-effect models were used to investigate the independent effects of probiotics on clinical outcomes. After 12 weeks, MMSE significantly improved cognition (P-Interaction < 0.0001), with post hoc comparisons identifying significantly more improvement in the B. longum intervention group (differences: 4.86, 95% CI: 3.91-5.81; P < 0.0001) compared with both the placebo and L. rhamnosus intervention groups (differences: 4.06, 95% CI: 3.11-5.01; P < 0.0001). There was no significant difference between the two intervention groups (differences: -0.8, 95% CI: -1.74 to 0.14; P = 0.09). In conclusion, this trial demonstrated that 12-week probiotic supplementation compared with placebo had beneficial effects on the cognition status of patients with AD.
机构:
Int Med Univ, Dept Nutr & Dietet, Sch Pharm & Hlth Sci, Kuala Lumpur 57000, MalaysiaInt Med Univ, Dept Nutr & Dietet, Sch Pharm & Hlth Sci, Kuala Lumpur 57000, Malaysia
Mazlyn, Mena Mustapha
Nagarajah, Lee Hun-Leong
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Vinayaka Mission Int Univ Coll, Petaling Jaya, Selangor Darul, MalaysiaInt Med Univ, Dept Nutr & Dietet, Sch Pharm & Hlth Sci, Kuala Lumpur 57000, Malaysia
Nagarajah, Lee Hun-Leong
Fatimah, Arshad
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Int Med Univ, Dept Nutr & Dietet, Sch Pharm & Hlth Sci, Kuala Lumpur 57000, MalaysiaInt Med Univ, Dept Nutr & Dietet, Sch Pharm & Hlth Sci, Kuala Lumpur 57000, Malaysia
Fatimah, Arshad
Norimah, A. Karim
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Natl Univ Malaysia, Sch Healthcare Sci, Fac Hlth Sci, Kuala Lumpur, MalaysiaInt Med Univ, Dept Nutr & Dietet, Sch Pharm & Hlth Sci, Kuala Lumpur 57000, Malaysia
Norimah, A. Karim
Goh, Khean-Lee
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Univ Malaya, Fac Med, Dept Med, Kuala Lumpur, MalaysiaInt Med Univ, Dept Nutr & Dietet, Sch Pharm & Hlth Sci, Kuala Lumpur 57000, Malaysia
机构:
Chinese Peoples Liberat Army Gen Hosp, Dept Clin Pharmacol, Med Supplier Ctr, Beijing 100853, Peoples R China
Chinese PLA Med Sch, Beijing 100853, Peoples R ChinaChinese Peoples Liberat Army Gen Hosp, Dept Clin Pharmacol, Med Supplier Ctr, Beijing 100853, Peoples R China
Hu, Yuan
Wang, Yichen
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Chinese Peoples Liberat Army Gen Hosp, Dept Clin Pharmacol, Med Supplier Ctr, Beijing 100853, Peoples R China
Chinese PLA Med Sch, Beijing 100853, Peoples R ChinaChinese Peoples Liberat Army Gen Hosp, Dept Clin Pharmacol, Med Supplier Ctr, Beijing 100853, Peoples R China
Wang, Yichen
Chen, Chao
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Chinese Peoples Liberat Army Gen Hosp, Dept Clin Pharmacol, Med Supplier Ctr, Beijing 100853, Peoples R ChinaChinese Peoples Liberat Army Gen Hosp, Dept Clin Pharmacol, Med Supplier Ctr, Beijing 100853, Peoples R China
Chen, Chao
Yang, Wenshan
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Chinese Peoples Liberat Army Gen Hosp, Dept Clin Pharmacol, Med Supplier Ctr, Beijing 100853, Peoples R China
Chinese PLA Med Sch, Beijing 100853, Peoples R ChinaChinese Peoples Liberat Army Gen Hosp, Dept Clin Pharmacol, Med Supplier Ctr, Beijing 100853, Peoples R China
Yang, Wenshan
Zhu, Weiyu
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Chinese Peoples Liberat Army Gen Hosp, Dept Clin Pharmacol, Med Supplier Ctr, Beijing 100853, Peoples R ChinaChinese Peoples Liberat Army Gen Hosp, Dept Clin Pharmacol, Med Supplier Ctr, Beijing 100853, Peoples R China
Zhu, Weiyu
Wang, Yuanbo
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Chinese Peoples Liberat Army Gen Hosp, Dept Clin Pharmacol, Med Supplier Ctr, Beijing 100853, Peoples R China
Chinese PLA Med Sch, Beijing 100853, Peoples R ChinaChinese Peoples Liberat Army Gen Hosp, Dept Clin Pharmacol, Med Supplier Ctr, Beijing 100853, Peoples R China
Wang, Yuanbo
Liu, Ping
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Chinese Peoples Liberat Army Gen Hosp, Dept Clin Pharmacol, Med Supplier Ctr, Beijing 100853, Peoples R ChinaChinese Peoples Liberat Army Gen Hosp, Dept Clin Pharmacol, Med Supplier Ctr, Beijing 100853, Peoples R China
机构:
Mt Sinai Sch Med, New York, NY USA
James J Peters VAMC, Bronx, NY 10468 USAMt Sinai Sch Med, New York, NY USA
Sano, M.
Bell, K. L.
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Columbia Univ, Dept Neurol, Med Ctr, New York, NY USAMt Sinai Sch Med, New York, NY USA
Bell, K. L.
Galasko, D.
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机构:
Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USAMt Sinai Sch Med, New York, NY USA
Galasko, D.
Galvin, J. E.
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机构:
NYU, Langone Med Ctr, Ctr Excellence Brain Aging, New York, NY USA
NYU, Langone Med Ctr, Alzheimer Dis Ctr, New York, NY USAMt Sinai Sch Med, New York, NY USA
Galvin, J. E.
Thomas, R. G.
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Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USAMt Sinai Sch Med, New York, NY USA
Thomas, R. G.
van Dyck, C. H.
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Yale Univ, Sch Med, Alzheimers Dis Res Unit, New Haven, CT USAMt Sinai Sch Med, New York, NY USA
van Dyck, C. H.
Aisen, P. S.
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Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USAMt Sinai Sch Med, New York, NY USA