Thrombospondin-1

被引：103
|
作者：
Adams, JC [1 ]
机构：
[1] UNIV LONDON UNIV COLL,DEPT BIOCHEM & MOL BIOL,LONDON WC1E 6BT,ENGLAND
来源：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 1997年 / 29卷 / 06期
基金：
英国惠康基金;
关键词：
D O I：
10.1016/S1357-2725(96)00171-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Thrombospondin-1 is a glycoprotein that is released from platelet alpha-granules in response to thrombin stimulation and that is also a transient component of extracellular matrix in developing and repairing tissues. It is a 420 kDa homotrimer, each subunit of which consists of multiple structural domains. A variety of factors regulate thrombospondin-1 expression and the protein is degraded by both extracellular and intracellular routes. Thrombospondin-1 functions as a cell adhesion molecule and also modulates cell movement, cell proliferation, neurite outgrowth and angiogenesis. The molecular mechanisms underlying these activities are beginning to be examined. Medical interest in thrombospondin-1 centres on its roles in haemostasis and its effects on angiogenesis. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码：861 / 865
页数：5
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