Facile one-pot synthesis of multifunctional polyphosphazene nanoparticles as multifunctional platform for tumor imaging

被引:14
|
作者
Wang, Zongfang [1 ]
Hu, Min [1 ]
Hu, Shugang [2 ]
Han, Jia [3 ]
Wang, Zhenzhen [3 ]
Chen, Yanke [3 ]
Huang, Cheng [3 ]
Fu, Lei [4 ]
Zhang, Zhenxi [4 ]
机构
[1] Xi An Jiao Tong Univ, Sch Sci, Dept Appl Chem, Xian 710049, Shaanxi, Peoples R China
[2] Xi An Jiao Tong Univ, Coll Med, Xian 710061, Shaanxi, Peoples R China
[3] Xi An Jiao Tong Univ, Coll Med, Key Lab Environm & Genes Related Dis, Xian 710061, Shaanxi, Peoples R China
[4] Xi An Jiao Tong Univ, Biomed Informat Engn Lab, State Minist Educ, Xian 710049, Shaanxi, Peoples R China
基金
中国国家自然科学基金;
关键词
One-pot; Imaging; Multifunctional; Theranostics; QUANTUM DOTS; BIOMEDICAL APPLICATIONS; POLYETHYLENE-GLYCOL; RECENT PROGRESS; CARBON DOTS; FLUORESCENT; MICROMOTORS; POLYMERIZATION; TEMPERATURE; DELIVERY;
D O I
10.1007/s00216-018-1035-5
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
By integrating imaging and drug-delivery in a single system, fluorescent nano-multifunctional imaging platforms can offer simultaneous diagnosis and therapy to diseases like cancer. However, the synthesis of such system involves a tedious, time-consuming, and multi-step process. Herein we report a facile method based on simple ultrasonication to synthesize highly cross-linked, monodispersed fluorescent polyphosphazene nanoparticles from hexachlorocyclotriphosphazene (HCCP) and dichlorofluorescein (FD). Various functional groups (folic acid, PEG-NH2, and methylene blue) can be "fastened" in situ onto the poly(cyclotriphosphazene-co-dichlorofluorescein) (PCTPDF) nanoparticles to expand its application as nano-multifunctional platform. All the nanoparticles were characterized spectrophotometrically, and morphology was established by the images obtained from scanning electron microscope (SEM). The synthesized multifunctional nanoparticles exhibited low toxicity and penetrated through the cytomembranes of human colon cancer (HCT 116) cells. When applied to in vivo tumor imaging using biologically engineered mouse model, methylene blue functionalized (PCTPDF@MB) nanoparticles exhibited excellent photodynamic activity and imaging ability. Thus, PCTPDF nanoplatform based on multi-functional fluorescent nanoparticles might offer an efficient solution to new age theranostics. Apart from diagnostics application, PCTPDF, as a nanoplatform, could also be utilized to achieve more comprehensive application in modern analytic chemistry.
引用
收藏
页码:3723 / 3730
页数:8
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