Concomitant Inhibition of mTORC1 and mTORC2 in Dendritic Cells Reduces SOCS3 Expression Resulting in Enhanced Immunoregulatory PD-L1 Expression and IL-10 Secretion

被引：0
|
作者：
Rosborough, B. R. [1 ,2 ]
Matta, B. M. [1 ,2 ]
Turnquist, H. R. [1 ,2 ]
Thomson, A. [1 ,2 ]
机构：
[1] Univ Pittsburgh, Surg, Pittsburgh, PA USA
[2] Starzl Transplantat Inst, Pittsburgh, PA USA
来源：
TRANSPLANTATION | 2012年 / 94卷 / 10期
关键词：
D O I：
10.1097/00007890-201211271-00023
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
1315
引用
收藏
页码：13 / 13
页数：1
相关论文
共 50 条
  • [31] Dandelion extract inhibited TNBC cells in TAMs microenvironment by suppressing IL-10/STAT3/PD-L1 signaling pathways
    Shuyan, Han
    Deng, Xin X.
    Hao, Hui F.
    Jiao, Yan N.
    Xue, Dong
    CANCER SCIENCE, 2022, 113 : 1333 - 1333
  • [32] Dual inhibition of STAT1 and STAT3 activation downregulates expression of PD-L1 in human breast cancer cells
    Nair, Varun Sasidharan
    Toor, Salman M.
    Ali, Bassam R.
    Elkord, Eyad
    EXPERT OPINION ON THERAPEUTIC TARGETS, 2018, 22 (06) : 547 - 557
  • [33] IL2-mediated modulation of small extracellular vesicles secretion and PD-L1 expression: a novel perspective for neutralizing immune suppression within cancer cells
    Noh, Soojeong
    Ryu, Suyeon
    Jung, Dokyung
    Shin, Sanghee
    Jung, Inseong
    Kang, Sung-Min
    Kim, Christine Seulki
    Choi, Sung-Jin
    Cho, Hanchae
    Schwammle, Melanie
    Jeong, Youngtae
    Bucher, Felicitas
    Choi, Il-Kyu
    Lee, Shin Yup
    Im, Sin-Hyeog
    Yea, Kyungmoo
    Baek, Moon-Chang
    CANCER COMMUNICATIONS, 2024,
  • [34] High PD-L1/CD86 MFI Ratio and IL-10 Secretion Characterize Maturation-Resistant Human Regulatory Dendritic Cells (DCregs) Generated for Clinical Testing in Transplantation.
    Zahorchak, A.
    Butterfield, L.
    Macedo, C.
    Hamm, D.
    Metes, D.
    Thomson, A.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2016, 16 : 334 - 335
  • [35] IL-10 producing B cells partially restore E2-mediated protection against EAE in PD-L1 deficient mice
    Zhang, Jun
    Benedek, Gil
    Bodhankar, Sheetal
    Lapato, Andrew
    Vandenbark, Arthur A.
    Offner, Halina
    JOURNAL OF NEUROIMMUNOLOGY, 2015, 285 : 129 - 136
  • [36] Differential Suppressive Effects of Selective PI3K and mTOR and Dual PI3K/mTORC1/C2 Inhibition on Long-Term Cultured Primary Human Acute Lymphoblastic Leukemia (ALL) Cells Implicate a Distinct Role of mTORC2
    Badura, Susanne
    Tesanovic, Tamara
    Pfeifer, Heike
    Hohnloser, Catherine
    Liebermann, Marcus
    Serve, Hubert
    Ruthardt, Martin
    Ottmann, Oliver G.
    BLOOD, 2010, 116 (21) : 454 - 454
  • [37] Inhibition of PD-L1 expression and restoration of T cell proliferation in tumor-coculture induced by NDRG2 expression in breast cancer cells
    Lim, J.
    Lee, A.
    Lim, S.
    Oh, J.
    Lim, J.
    Yang, Y.
    Lee, M.
    FEBS OPEN BIO, 2022, 12 : 115 - 115
  • [38] Nicotine treatment regulates PD-L1 and PD-L2 expression via inhibition of Akt pathway in HER2-type breast cancer cells
    Murayama, Masanori A.
    Takada, Erika
    Takai, Kenji
    Arimitsu, Nagisa
    Shimizu, Jun
    Suzuki, Tomoko
    Suzuki, Noboru
    PLOS ONE, 2022, 17 (01):
  • [39] The Activation of MAPK in Melanoma Cells Resistant to BRAF Inhibition Promotes PD-L1 Expression That Is Reversible by MEK and PI3K Inhibition
    Jiang, Xiaofeng
    Zhou, Jun
    Giobbie-Hurder, Anita
    Wargo, Jennifer
    Hodi, F. Stephen
    CLINICAL CANCER RESEARCH, 2013, 19 (03) : 598 - 609
  • [40] Inhibition of TCA cycle improves the anti-PD-1 immunotherapy efficacy in melanoma cells via ATF3-mediated PD-L1 expression and glycolysis
    Liu, Nian
    Yan, Mingjie
    Tao, Qian
    Wu, Jie
    Chen, Jing
    Chen, Xiang
    Peng, Cong
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2023, 11 (09)
12345