Axially Chiral C2-Symmetric N-Heterocyclic Carbene (NHC) Palladium Complex-Catalyzed Asymmetric Fluorination and Amination of Oxindoles

被引：32

作者：

Zhang Rui ^{[1
,2
]}

Wang De ^{[1
,2
]}

Xu Qin ^{[1
,2
]}

Jiang Jiajun ^{[1
,2
]}

Shi Min ^{[1
,2
,3
]}

机构：

[1] E China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China

[2] E China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Shanghai 200237, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2012年 / 30卷 / 06期

基金：

中国国家自然科学基金;

关键词：

chiral C2-symmetric N-heterocyclic carbene (NHC) palladium diaquo complex; (S)-BINAM; asymmetric fluorination of oxindoles; N-fluorobenzenesulfonimide (NFSI); 1-chloromethyl-4-fluoro-1; 4-diazoniabicyclo[2; 2; 2]octane bis(tetrafluoroborate) (selectfluor); ORGANOCATALYTIC ALPHA-FLUORINATION; BETA-KETO PHOSPHONATES; ENANTIOSELECTIVE FLUORINATION; ARYLBORONIC ACIDS; ELECTROPHILIC FLUORINATION; MEDICINAL CHEMISTRY; ATOM-TRANSFER; IONIC LIQUID; CHLORINATION; COMBINATIONS;

D O I：

10.1002/cjoc.201200289

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chiral C2-symmetric N-heterocyclic carbene (NHC) palladium diaquo complex 5b prepared from (S)-BINAM was found to be a fairly effective catalyst for the enantioselective asymmetric fluorination of oxindoles to give the corresponding products in moderate enantioselectivities along with good to excellent yields.

引用

页码：1295 / 1304

页数：10

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