50th anniversary of cisplatin

被引：46

作者：

Rancoule, Chloe ^{[1
,2
]}

Guy, Jean-Baptiste ^{[1
,2
]}

Vallard, Alexis ^{[1
]}

Ben Mrad, Majed ^{[1
]}

Rehailia, Amel ^{[1
]}

Magne, Nicolas ^{[1
,2
]}

机构：

[1] Inst Cancerol Lucien Neuwirth, Dept Radiotherapie, 108 Bis,Ave Albert Raimond,BP 60008, F-42271 St Priest En Jarez, France

[2] CNRS UMR 5822, Lab Radiobiol Cellulaire & Mol Lyon Sud, 165 Chemin Grand Revoyet,BP 12, F-69921 Oullins, France

来源：

BULLETIN DU CANCER | 2017年 / 104卷 / 02期

关键词：

Cisplatin; Chemotherapy; Carboplatin; Oxaliplatin; Resistance; Toxicities; CELL LUNG-CANCER; HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY; ADENOSINE-TRIPHOSPHATASE ATP7B; ANTICANCER DRUG CISPLATIN; ADVANCED OVARIAN-CANCER; MOLECULAR-MECHANISMS; PLATINUM COMPOUNDS; RADIATION-THERAPY; TUMOR RESPONSE; TREATMENT TIME;

D O I：

10.1016/j.bulcan.2016.11.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have just celebrated the 50th anniversary of cisplatin cytotoxic potential discovery. It is time to take stock... and it seems mainly positive. This drug, that revolutionized the treatment of many cancer types, continues to be the most widely prescribed chemotherapy. Despite significant toxicities, resistance mechanisms associated with treatment failures, and unresolved questions about its mechanism of action, the use of this cytotoxic agent remains unwavering. The interest concerning this "old'' invincible drug has not yet abated. Indeed many research axes are in the news. New platinum salts agents are tested, new cisplatin formulations are developed to target tumor cells more efficiently, and new combinations are established to increase the cytotoxic potency of cisplatin or overcome the resistance mechanisms.

引用

页码：167 / 176

页数：10

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