Molecular Mechanisms of Viral Immune Evasion Proteins to Inhibit MHC Class I Antigen Processing and Presentation

被引：13

作者：

Zhou, Fang ^{[1
]}

机构：

[1] Univ Queensland, Princess Alexandra Hosp, Diamantina Inst Canc Immunol & Metab Med, Brisbane, Qld 4102, Australia

来源：

INTERNATIONAL REVIEWS OF IMMUNOLOGY | 2009年 / 28卷 / 05期

关键词：

viral immune evasion protein; MHC class I antigen presentation; IFN-gamma; JAK/STAT signal transduction pathway; CTL epitope; IRF-1; MAJOR HISTOCOMPATIBILITY COMPLEX; PEPTIDE-LOADING COMPLEX; UBIQUITIN-CONJUGATING ENZYME; INTERFERON REGULATORY FACTOR; SIMPLEX-VIRUS TYPE-1; TRANS-GOLGI NETWORK; DOUBLE-STRANDED-RNA; INFLUENZA-B VIRUS; CELL-CYCLE ARREST; KINASE PKR;

D O I：

10.1080/08830180903013034

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Viral products inhibit MHC class I antigen processing and presentation via three major pathways: inhibition of major histocompatibility complex WHO class I expression on cells, blockade of peptide trafficking and loading on MHC class I molecules, and inhibition of peptide generation in host cells. Viral products also interfere with IFN-gamma-mediated JAK/STAT signal transduction in cells. These results imply that viral proteins probably inhibit the function of IFN-gamma in MHC class I antigen presentation via inactivation of JAK/STAT signal transduction in host cells. Mechanisms of viral products to inhibit IFN-gamma-mediated MHC class I antigen presentation were summarized in this literature review.

引用

页码：376 / 393

页数：18

共 50 条

[41] MOLECULAR MECHANISMS OF ANTIGEN PRESENTATION BY MHC MOLECULES
COLOMBANI, J
BULLETIN DE L INSTITUT PASTEUR, 1991, 89 (02): : 109 - 132
[42] Molecular aspects of MHC class I-restricted antigen processing
Cresswell, P.
IMMUNOLOGY, 2013, 140 : 7 - 7
[43] Host immune system strikes back Autophagy-mediated antigen presentation bypasses viral blockade of the classic MHC class I processing pathway
Tey, Siok-Keen
Khanna, Rajiv
AUTOPHAGY, 2012, 8 (12) : 1839 - 1841
[44] Autophagy proteins in antigen processing for presentation on MHC molecules
Munz, Christian
IMMUNOLOGICAL REVIEWS, 2016, 272 (01) : 17 - 27
[45] MHC class I antigen processing pathways
Maffei, A
Papadopoulos, K
Harris, PE
HUMAN IMMUNOLOGY, 1997, 54 (02) : 91 - 103
[46] The proteasorne and MHC class I antigen processing
Kloetzel, PM
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2004, 1695 (1-3): : 225 - 233
[47] To the bat MHC! Antigen processing and presentation during viral infection
Woon, A.
Wynne, J.
Dudek, N.
Ng, J.
Baker, M.
Wang, L.
Purcell, A.
EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, 46 : 95 - 95
[48] Human Neonatal Dendritic Cells Are Competent in MHC Class I Antigen Processing and Presentation
Gold, Marielle C.
Robinson, Tammie L.
Cook, Matthew S.
Byrd, Laura K.
Ehlinger, Heather D.
Lewinsohn, David M.
Lewinsohn, Deborah A.
PLOS ONE, 2007, 2 (09):
[49] Suppression of the Macrophage Proteasome by Ethanol Impairs MHC Class I Antigen Processing and Presentation
D'Souza, Alain J.
Desai, Shyamal D.
Rudner, Xiaowen L.
Kelly, Michelle N.
Ruan, SanBao
Shellito, Judd E.
PLOS ONE, 2013, 8 (02):
[50] Antigen presentation by MHC class I and II molecules
Neefjes, JJ
IMMUNOBIOLOGY, 1996, 195 (4-5) : 456 - 460

← 1 2 3 4 5 →