THE MANAGEMENT OF DIABETIC PERIPHERAL NEUROPATHY WITH VITAMIN B1, B6 AND B12 GIVEN IN COMBINATION AND ITS EFFICACY

Objective: To ascertain the vitamin B1, B6 and B12 efficacy given in combination in the treatment of diabetic peripheral neuropathy. Study Design: A series of descriptive cases. Place and Duration: In the Medical unit II of Jinnah Hospital Lahore for one year period from October 2017 to September 2018. Methods: A total of 310 patients with sample size selected using unintentional sampling technique. Patients with diabetic peripheral neuropathy, diabetes mellitus, Metabolism and Endocrinology problem were selected. Volunteers were given Neurobion Tab (100 mg vitamin B1, 100 mg vitamin B6, 200 mcg vitamin B12) two times daily for 28 days( 4 weeks). After 4 weeks of initial visit patient was called for follow-up. It was concluded that the efficacy was documented with an improvement in minimum 2 pain points from the baseline evaluated by the numerical pain rating scale. Results: The patients mean age was 46.7 +/- 8.6. Of the 310 patients, 177 (57.0%) were male and the remaining female133 (42.90%). The diabetes duration was as follows: 0-10 years in 84 patients (27.08%), 11-20 years in 138 patients (45.08%) and 21-30 years in 76 patients (25.28%) and only (3,6%)> 30 years. in 12 patients. In the treatment of diabetic peripheral neuropathy, B1, B6 and B12 combination was found to be effective in 270 patients (86.94%). Conclusion: In diabetic peripheral neuropathy treatment B1, B6 and B12 given in combination is effective in pain relief. <bold> </bold>