Modular modelling of signalling pathways and their cross-talk

被引：10
|
作者：
Donaldson, Robin [1 ]
Calder, Muffy [1 ]
机构：
[1] Univ Glasgow, Sch Comp Sci, Glasgow G12 8QQ, Lanark, Scotland
来源：
THEORETICAL COMPUTER SCIENCE | 2012年 / 456卷
基金：
英国工程与自然科学研究理事会;
关键词：
Signalling pathways; Cross-talk; Signalling networks; Modelling; Biological modules; PETRI NETS; MAPK;
D O I：
10.1016/j.tcs.2012.07.003
中图分类号：
TP301 [理论、方法];
学科分类号：
081202 ;
摘要：
Signalling pathways are well-known abstractions that explain the mechanisms whereby cells respond to signals. Collections of pathways form networks, and interactions between pathways in a network, known as cross-talk, enables further complex signalling behaviours. While there are several formal modelling approaches for signalling pathways, none make cross-talk explicit; the aim of this paper is to define and categorise cross-talk in a rigorous way. We define a modular approach to pathway and network modelling, based on the module construct in the PRISM modelling language, and a set of generic signalling modules. Five different types of cross-talk are defined according to various biologically meaningful combinations of variable sharing, synchronisation labels and reaction renaming. The approach is illustrated with a case-study analysis of cross-talk between the TGF-beta, WNT and MAPK pathways. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：30 / 50
页数：21
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