Effect of glucocorticoids on 3-nitropropionic acid-induced oxidative stress in synaptosomes

被引：38

作者：

Montilla, P ^{[1
]}

Túnez, I ^{[1
]}

Muñoz, MC ^{[1
]}

Salcedo, M ^{[1
]}

Feijóo, M ^{[1
]}

Muñoz-Castañeda, JR ^{[1
]}

Bujalance, I ^{[1
]}

机构：

[1] Univ Cordoba, Sch Med, Dept Biochem & Mol Biol, E-14004 Cordoba, Spain

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2004年 / 488卷 / 1-3期

关键词：

3-nitropropionic acid; Huntington's disease; oxidative stress; glucocorticoid;

D O I：

10.1016/j.ejphar.2004.02.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present study with rat striatal and cortical synaptosomes evaluated the effect of dexamethasone (300 mug/kg i.p./day) with and without simultaneous adrenalectomy on the oxidative stress induced by 3-nitropropionic acid (20 mg/kg/day for 4 days). Adrenalectomy enhanced the oxidative stress induced by 3-nitropropionic acid. These changes were prevented by previous and simultaneous administration of dexamethasone. Adrenalectomy alone induced oxidative stress with decreases in succinate dehydrogenase activity. Our results revealed that adrenal glucocorticoids, and especially dexamethasone (synthetic glucocorticoid), have a protective effect against oxidative stress induced by 3-nitropropionic acid in some brain regions of the Wistar rat. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：19 / 25

页数：7

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