Introduction: Cementless knee arthroplasty becomes more and more popular worldwide. At the beginning of endoprosthetics era, cementless implants showed unsatisfactory results. However, surgical technologies develop rapidly and nowadays the cementless fixation shows better outcomes. Objectives: To analyze the experience of total knee arthroplasty using cementless fixation for the treatment of advanced arthritis of the knee. Methods: We operated on 130 patients. The mean follow-up duration was 36 months. In 70 patients we used cementless fixation and in 60 patients we used implants with cemented fixation. To evaluate the results, we used KOOS scale and WOMAC scale. We also evaluated the mean duration of surgical intervention and blood loss. Results: In the cementless group WOMAC and KOOS scales scores before the operation were 198,2 ( +/- 35.7) and 23,1 ( +/- 3.4), respectively, and in the cemented group it was 199.3( +/- 36.8) and 24.9 ( +/- 2.1), respectively (p > 0,05). One year after the operation, KOOS and WOMAC scores were 54.5( +/- 12.6) and 83.6( +/- 8,.2) in the cementless group and 78.9( +/- 4.6) and 66.9( +/- 5.7) in the cemented group(p < 0,05)., respectively. Intraoperative blood loss was 255( +/- 89,3) in the cemented group and 315( +/- 52,1) in cementless group (p < 0,05). Postoperative blood loss was 515( +/- 119, 5) and 440( +/- 129,3)) (p < 0,05), respectively. Mean duration of intervention was 78 min ( +/- 6,8) in cemented group and 64 min ( +/- 8,7) in cementless group (p < 0,05). Conclusions: 1 We have better functional results using implants with cementless fixation. 2 There was a greater intraoperative and postoperative blood loss in cementless group. 3 Cementless knee arthroplasty associated with shorter duration of intervention than cemented.