Diterpene Constituents of Euphorbia exigua L. and Multidrug Resistance Reversing Activity of the Isolated Diterpenes

被引：9

作者：

Redei, Dora ^{[1
]}

Boros, Klara ^{[1
]}

Forgo, Peter ^{[1
]}

Molnar, Joseph ^{[2
]}

Kele, Zoltan ^{[3
]}

Palinko, Istvan ^{[4
]}

Pinke, Gyula ^{[5
]}

Hohmann, Judit ^{[1
]}

机构：

[1] Univ Szeged, Dept Pharmacognosy, H-6720 Szeged, Hungary

[2] Univ Szeged, Dept Med Microbiol & Immunobiol, H-6720 Szeged, Hungary

[3] Univ Szeged, Dept Med Chem, H-6720 Szeged, Hungary

[4] Univ Szeged, Dept Organ Chem, H-6720 Szeged, Hungary

[5] Univ West Hungary, Dept Bot, Fac Agr & Food Sci, H-9200 Mosonmagyarovar, Hungary

来源：

CHEMISTRY & BIODIVERSITY | 2015年 / 12卷 / 08期

基金：

匈牙利科学研究基金会;

关键词：

Euphorbia exigua; Jatrophane; Diterpene; Multidrug resistance; P-Glycoprotein; P-GLYCOPROTEIN; JATROPHANE DITERPENOIDS; MACROCYCLIC DITERPENES; CANCER-CELLS; MODULATORS;

D O I：

10.1002/cbdv.201400260

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phytochemical investigation of the MeOH extract obtained from the aerial parts of the annual weed Euphorbia exigua L. resulted in the isolation of two novel (1, 2) and one known (3) jatrophane diterpenes. Their structures were established by extensive 1D- and 2D-NMR spectroscopy and HR-ESI-MS. The isolated compounds were evaluated for multidrug resistance (MDR) reversing activity on human MDR gene-transfected L5178 mouse lymphoma cells; and all three compounds were found to modulate the intracellular drug accumulation.

引用

页码：1214 / 1221

页数：8

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