Synthesis of a versatile (S)-3-(hydroxymethyl)butane-1,2,4-triol building block and its application for the stereoselective synthesis of N-homoceramides

被引：6

作者：

Hillaert, U ^{[1
]}

Van Calenbergh, S ^{[1
]}

机构：

[1] Univ Ghent, Med Chem Lab, Fac Pharmaceut Sci, B-9000 Ghent, Belgium

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 26期

关键词：

D O I：

10.1021/ol052335x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A versatile (S)-3-(hydroxymethyl)butane-1,2,4-triol building block has been synthesized starting from D-isoascorbic acid, a common food preservative. The key transformation in this approach was the introduction of branching through a high yield and fully regioselective epoxide opening. This flexible synthon has been elaborated to a new class of (dihydro-)N-homo(phyto)ceramides.

引用

页码：5769 / 5772

页数：4

共 45 条

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