Plasma lipidome reveals critical illness and recovery from human Ebola virus disease

被引:61
|
作者
Kyle, J. E. [1 ]
Burnum-Johnson, K. E. [1 ]
Wendler, J. P. [1 ]
Eisfeld, A. J. [2 ]
Halfmann, Peter J. [2 ]
Watanabe, Tokiko [3 ]
Sahr, Foday [4 ]
Smith, R. D. [1 ]
Kawaoka, Y. [2 ,3 ,5 ]
Waters, K. M. [1 ]
Metz, T. O. [1 ]
机构
[1] Pacific Northwest Natl Lab, Biol Sci Div, Richland, WA 99352 USA
[2] Univ Wisconsin, Dept Pathobiol Sci, Madison, WI 53711 USA
[3] Univ Tokyo, Div Virol, Dept Microbiol & Immunol, Inst Med Sci, Tokyo 1088639, Japan
[4] 34th Regimental Mil Hosp Wilberforce, Freetown, Sierra Leone
[5] Univ Tokyo, Int Res Ctr Infect Dis, Inst Med Sci, Tokyo 1088639, Japan
关键词
lipidomics; Ebola; critical illness; therapies; mass spectrometry; GAMMA-LINOLENIC ACID; EXTRACELLULAR VESICLES; HEMORRHAGIC-FEVER; ADIPOSE-TISSUE; EMERGING ROLE; PHOSPHATIDYLSERINE; BLOOD; MICROPARTICLES; EXOSOMES; PHOSPHATIDYLCHOLINE;
D O I
10.1073/pnas.1815356116
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Ebola virus disease (EVD) often leads to severe and fatal outcomes in humans with early supportive care increasing the chances of survival. Profiling the human plasma lipidome provides insight into critical illness as well as diseased states, as lipids have essential roles as membrane structural components, signaling molecules, and energy sources. Here we show that the plasma lipidomes of EVD survivors and fatalities from Sierra Leone, infected during the 2014-2016 Ebola virus outbreak, were profoundly altered. Focusing on how lipids are associated in human plasma, while factoring in the state of critical illness, we found that lipidome changes were related to EVD outcome and could identify states of disease and recovery. Specific changes in the lipidome suggested contributions from extracellular vesicles, viremia, liver dysfunction, apoptosis, autophagy, and general critical illness, and we identified possible targets for therapies enhancing EVD survival.
引用
收藏
页码:3919 / 3928
页数:10
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