Thermoresponsive hydrogels based on poly(N-isopropylacrylamide)/chondroitin sulfate

被引：33

作者：

Varghese, Justin M. ^{[1
]}

Ismail, Yahya A. ^{[1
]}

Lee, Chang Kee ^{[1
,2
]}

Shin, Kwang Min ^{[1
,2
]}

Shin, Min Yoon ^{[1
,2
]}

Kim, Sun I. ^{[2
]}

So, Insuk ^{[1
,3
]}

Kim, Seon Jeong ^{[1
,2
]}

机构：

[1] Hanyang Univ, Ctr Bioartificial Muscle, Seoul 133791, South Korea

[2] Hanyang Univ, Dept Biomed Engn, Seoul 133791, South Korea

[3] Seoul Natl Univ, Dept Physiol, Seoul 110744, South Korea

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2008年 / 135卷 / 01期

关键词：

Chondroitin sulfate; PNIPAm; Hydrogel; Thermosensitive; Swelling;

D O I：

10.1016/j.snb.2008.09.001

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A fast, thermoresponsive hydrogel composed of poly(N-isopropylacrylamide) (PNIPAm) and chondroitin sulfate (ChS) was synthesized using precipitation polymerization. ChS was introduced to increase the water absorption of the PNIPAm hydrogel. and the precipitation polymerization method was used to induce a porous network morphology to enhance the thermal response of the hydrogel. PNIPAm/ChS hydrogels (15:7.5 wt.%) underwent a very fast deswelling, within a period of approximately 2 min, due to the presence of a large free water content (similar to 90-94%), which was associated with the interconnected filamentous morphology within the hydrogel. The swelling ratio was greatly enhanced by the addition of ChS. The hydrogels exhibited stable thermoactuation behavior, following a volume change of 75% while cycling the temperature between 20 and 45 degrees C. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：336 / 341

页数：6

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