Structure, G protein activation, and functional relevance of the cardiac G protein-gated K+ channel, IKAch

被引：31
|
作者：
Wickman, K
Krapivinsky, G
Corey, S
Kennedy, M
Nemec, J
Medina, I
Clapham, DE
机构：
[1] Harvard Univ, Sch Med, Childrens Hosp, Howard Hughes Med Inst,Dept Neurobiol, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Childrens Hosp, Howard Hughes Med Inst,Dept Cardiol, Boston, MA 02115 USA
[3] Mayo Clin & Mayo Fdn, Dept Internal Med, Div Cardiovasc Dis, Rochester, MN 55905 USA
来源：
MOLECULAR AND FUNCTIONAL DIVERSITY OF ION CHANNELS AND RECEPTORS | 1999年 / 868卷
关键词：
D O I：
10.1111/j.1749-6632.1999.tb11300.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The muscarinic-gated atrial potassium channel I(KACh) has been well characterized functionally, and has been an excellent model system for studying G protein/effector interactions. Complementary DNAs encoding the composite subunits of I(KACh) have been identified, allowing direct probing of structural and functional features of the channel. Here, we highlight recent approaches taken in our laboratory to determine the oligomeric structure of native cardiac I(KACh), the mechanism of activation of I(KACh) by G proteins, and the relevance of I(KACh) to cardiac physiology.
引用
收藏
页码：386 / 398
页数：13
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