Plasma betacarotene in Alzheimer's disease.: Association with cerebrospinaffluid beta-amyloid 1-40, (Abeta40), beta-amyloid 1-42 (Abeta42) and total Tau

被引：0

作者：

Stuerenburg, HJ ^{[1
]}

Ganzer, S

Müller-Thomsen, T

机构：

[1] Median Klin Bad Suelze, Dept Neurol, D-18334 Bad Suelze, Germany

[2] Univ Hosp Hamburg Eppendorf, Clin Psychiat & Psychotherapy, Hamburg, Germany

[3] Psychiat Clin Haecklingen, Lueneburg Uelzen, Germany

来源：

NEUROENDOCRINOLOGY LETTERS | 2005年 / 26卷 / 06期

关键词：

plasma betacarotene; Alzheimer's disease; cerebrospinal fluid; beta-amyloid; 1-42; 1-40; total Tau; MMSE; anti-amyloidogenic; diet;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We studied the plasma betacarotene concentrations in 40 Alzheimer's disease patients and the association with cerebrospinal fluid beta-amyloid 1-40, (Abeta40), cerebrospinal fluid beta-amyloid 1-42 (Abeta42) and cerebrospinal fluid total Tau. We found that patients with plasma beta carotene levels below the 25th percentile had 55% reduced ratios of Abeta40/Tau and 51% reduced ratios of Abeta 40/Abeta 42 compared with patients in the highest quartile. Mean Tau concentrations in the lowest quartile of plasma beta-carotene levels were 74% higher compared with the highest quartile of plasma beta-carotene levels. Thus, we could demonstrate an statistically significant association between beta carotene levels in plasma and neurochemical markers in the cerebrospinal fluid of Alzheimer's disease patients.

引用

页码：696 / 698

页数：3

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