Label-free cocaine aptasensor based on a long-period fiber grating

被引：21

作者：

Celebanska, Anna ^{[1
]}

Chiniforooshan, Yasser ^{[1
]}

Janik, Monika ^{[1
]}

Mikulic, Predrag ^{[1
]}

Sellamuthu, Balasubramanian ^{[2
,3
]}

Walsh, Ryan ^{[2
]}

Perreault, Jonathan ^{[2
]}

Bock, Wojtek J. ^{[1
]}

机构：

[1] Univ Quebec Outaouais, Photon Res Ctr, 101 Rue St Jean Bosco, Gatineau, PQ J8X 3X7, Canada

[2] INRS Inst Armand Frappier Ctr, 531 Blvd Prairies, Laval, PQ H7V 1B7, Canada

[3] Univ Montreal, CHUM, Ctr Rech, 900 Rue St Denis, Montreal, PQ H2X 0A9, Canada

来源：

OPTICS LETTERS | 2019年 / 44卷 / 10期

基金：

加拿大自然科学与工程研究理事会;

关键词：

APTAMER-BASED BIOSENSOR; SOCIAL IMPLICATIONS; SENSORS; TOXICITY; HISTORY;

D O I：

10.1364/OL.44.002482

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

In this Letter, we combined a promising bioreceptor, a cocaine aptamer MN6, with an ultrasensitive optical platform long-period fiber grating (LPFG) to create a new cocaine biosensor. The cocaine induces a conformational rearrangement of the aptamer which changes the refractive index around the LPFG producing a measurable shift of the transmission spectrum. We were able to track subtle interaction between the receptor and cocaine molecules over a concentration range of 25 to 100 mu M. The presented biosensor does not require labeling or signal enhancement, resulting in a simple user-friendly device. (C) 2019 Optical Society of America

引用

页码：2482 / 2485

页数：4

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