Baylis-Hillman Reactions of 2-(Trifluoroacetyl)-1,3-azoles

被引：9

作者：

Khodakovskiy, Pavel V. ^{[1
,2
]}

Volochnyuk, Dmitriy M. ^{[1
,3
]}

Shivanyuk, Alexander ^{[1
,2
]}

Shishkin, Oleg V. ^{[4
]}

Tolmachev, Andrey A. ^{[2
]}

机构：

[1] Enamine Ltd, UA-01103 Kiev, Ukraine

[2] Natl Taras Shevchenko Univ, UA-01033 Kiev 33, Ukraine

[3] Natl Acad Sci Ukraine, Inst Organ Chem, UA-02094 Kiev 94, Ukraine

[4] Natl Acad Sci Ukraine, Inst Scintillat Mat, UA-61001 Kharkov, Ukraine

来源：

SYNTHESIS-STUTTGART | 2008年 / 20期

关键词：

Baylis-Hillman reaction; 1,3-azoles; Michael additions; trifluoromethyl substituted; allylic alcohols;

D O I：

10.1055/s-0028-1083150

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-(Trifluoroacetyl)-1,3-azoles readily react with methyl acrylate and acrylonitrile under Baylis-Hillman reaction conditions to afford heterocyclic trifluoromethyl-containing allylic alcohols in 36-97% yields. The thus obtained Baylis-Hillman adducts readily undergo Michael addition reactions with various nucleophiles.

引用

页码：3245 / 3252

页数：8

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