Baylis-Hillman Reactions of 2-(Trifluoroacetyl)-1,3-azoles

被引：9
|
作者：
Khodakovskiy, Pavel V. [1 ,2 ]
Volochnyuk, Dmitriy M. [1 ,3 ]
Shivanyuk, Alexander [1 ,2 ]
Shishkin, Oleg V. [4 ]
Tolmachev, Andrey A. [2 ]
机构：
[1] Enamine Ltd, UA-01103 Kiev, Ukraine
[2] Natl Taras Shevchenko Univ, UA-01033 Kiev 33, Ukraine
[3] Natl Acad Sci Ukraine, Inst Organ Chem, UA-02094 Kiev 94, Ukraine
[4] Natl Acad Sci Ukraine, Inst Scintillat Mat, UA-61001 Kharkov, Ukraine
来源：
SYNTHESIS-STUTTGART | 2008年 / 20期
关键词：
Baylis-Hillman reaction; 1,3-azoles; Michael additions; trifluoromethyl substituted; allylic alcohols;
D O I：
10.1055/s-0028-1083150
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
2-(Trifluoroacetyl)-1,3-azoles readily react with methyl acrylate and acrylonitrile under Baylis-Hillman reaction conditions to afford heterocyclic trifluoromethyl-containing allylic alcohols in 36-97% yields. The thus obtained Baylis-Hillman adducts readily undergo Michael addition reactions with various nucleophiles.
引用
收藏
页码：3245 / 3252
页数：8
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