The Synthesis of 7-Substituted-2,3-dihydropyrido [4,3-d] pyridazine-1,4-diones and 1,4-Dioxo-7-substituted1,2,3,4-tetrahydropyrido[4,3-d] pyridazine 6-Oxides from Methyl Ketones

被引：3

作者：

Prek, Benjamin ^{[1
]}

Stanovnik, Branko ^{[1
]}

机构：

[1] Univ Ljubljana, Fac Chem & Chem Technol, Vecna Pot 113,POB 537, Ljubljana 1000, Slovenia

来源：

ACTA CHIMICA SLOVENICA | 2017年 / 64卷 / 04期

关键词：

methyl ketones; 7-substituted-2,3-dihydropyrido[4,3-d] pyridazine-1,4-diones; 1,4-dioxo-7-substituted1,2,3,4-tetrahydropyrido[4,3-d] pyridazine 6-oxides; ELECTRON-POOR ACETYLENES; METAL-FREE SYNTHESIS; 2+2 CYCLOADDITION; APLYSINOPSIN ANALOGS; N-OXIDES; DERIVATIVES; PYRIDINE; ENAMINONES; 3-(DIMETHYLAMINO)PROPENOATES; HETEROCYCLES;

D O I：

10.17344/acsi.2017.3695

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A general four-step transformation of alkyl, cycloalkyl, aryl, and heteroaryl methyl ketones via 3-(dimethylamino)-1-substituted- prop-2-en-1-ones, followed by microwave [2+ 2] cycloaddition of dimethyl acetylenedicarboxylate, cyclization of (2E, 3E)-2-[(dimethylamino) methylene]-3-(2-substituted) succinates with ammonia or hydroxylamine hydrochloride into 2-substituted-pyridine-4,5-dicarboxylates and their N-oxides and final cyclization with hydrazine hydrate into of 7-substituted-2,3-dihydropyrido[3,4-d] pyridazine-1,4-diones and 1,4-dioxo-7-substituted-1,2,3,4-tetrahydropyrido[4,3-d] pyridazine 6-oxides is shown.

引用

页码：798 / 803

页数：6

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