A metal-free approach for transamidation of amides with amines in aqueous media

被引：38
|
作者：
Srinivas, Mahesuni [1 ,2 ]
Hudwekar, Abhinandan D. [1 ,2 ]
Venkateswarlu, Vunnam [1 ,2 ]
Reddy, G. Lakshma [1 ,2 ]
Kumar, K. A. Aravinda [1 ]
Vishwakarma, Ram A. [1 ,2 ]
Sawant, Sanghapal D. [1 ,2 ]
机构：
[1] CSIR Indian Inst Integrat Med, Div Med Chem, Jammu 180001, India
[2] Anusandhan Bhawan, Acad Sci & Innovat Res, New Delhi 110001, India
来源：
TETRAHEDRON LETTERS | 2015年 / 56卷 / 33期
关键词：
Amide; Amine; K2S2O8; Metal-free; Transamidation; Aqueous conditions; III-CATALYZED TRANSAMIDATION; N-TRIFLUOROACYLATION; BOND FORMATION; CARBOXAMIDES; ARYLAMINES; PEPTIDES; CHLORIDE;
D O I：
10.1016/j.tetlet.2015.06.052
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient, environmentally benign and a mild protocol for transamidation of amides with a variety of amines in the presence of K2S2O8 using stoichiometric quantity in aqueous conditions has been established. This method works under conventional thermal conditions and in microwave irradiation as well. A series of amides have been prepared using this reaction and this is a greener protocol for transamidation, which offers a diverse kind of substrate scope with exclusive product formation (yields 90-98%). (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4775 / 4779
页数：5
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