In vitro activity of 11 antimicrobial agents, including gatifloxacin and GAR936, tested against clinical isolates of Mycobacterium marinum

In vitro activities of I I antimicrobial agents were determined using Etest (AB BIODISK, Solna, Sweden) against 37 clinical isolates of Mycobacterium marinum, The most potent agent (MIC50. 0.047 mug/mL) was trimethoprim/sulfamethoxazole, but only 91.9% would be categorized as susceptible. Several agents had a complete spectrum of activity including gatifloxacin (MIC90. 0.38 mug/mL), minocycline (MIC90. 2 mug/mL), tetracycline (MIC90, 2 mug/mL) and amikacin (MIC90. 3 mug/mL). The new glycylcycline, GAR936, had a similar potency (MIC90. 3 mug/mL) to that of the parent minocycline compound (MIC90. 2 mug/mL), but the range of MIC values extended to 24 mug/mL. Numerous options appear to exist for the contemporary therapy of M. marinum infections including some newer fluoroquinolones and derivatives of tetracycline (doxycycline, minocycline, GAR936). (C) 2002 Elsevier Science Inc. All rights reserved.