Expression of hMLH1, hMSH2 and hMSH6 in Small Intestinal Carcinomas

被引：12

作者：

Gu, Mi Jin ^{[1
]}

Bae, Young Kyung ^{[1
]}

Kim, Aeri ^{[1
]}

Hong, Seung-Mo ^{[2
]}

Yu, Eunsil ^{[2
]}

Kim, Jihun ^{[2
]}

Jang, Kee-Taek ^{[3
]}

Chang, Hee-Kyung ^{[4
]}

Jung, Eun Sun ^{[5
]}

Bae, Han-Ik ^{[6
]}

Yoon, Ghil Suk ^{[6
]}

Kim, Joon Mee ^{[7
]}

Kim, Jung Yeon ^{[8
]}

Kim, Gwang Il ^{[9
]}

Oh, Young-Ha ^{[10
]}

Jang, Kyu Yun ^{[11
]}

Jun, Sun-Young ^{[12
]}

Eom, Dae Woon ^{[13
]}

Kwon, Kye Won ^{[14
]}

Kang, Gyeong Hoon ^{[15
]}

Park, Jae Bok ^{[16
]}

Hong, Soon Won ^{[17
]}

Jung, Soo Jin ^{[18
]}

Lee, Ji Shin ^{[19
]}

机构：

[1] Yeungnam Univ, Coll Med, Dept Pathol, Taegu 705717, South Korea

[2] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pathol, Seoul, South Korea

[3] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Pathol, Seoul, South Korea

[4] Kosin Univ, Coll Med, Dept Pathol, Pusan, South Korea

[5] Catholic Univ Korea, Coll Med, Dept Pathol, Seoul, South Korea

[6] Kyungpook Natl Univ, Sch Med, Dept Pathol, Taegu, South Korea

[7] Inha Univ, Coll Med, Dept Pathol, Inchon, South Korea

[8] Inje Univ, Sanggye Paik Hosp, Dept Pathol, Seoul, South Korea

[9] CHA Univ, CHA Bundang Med Ctr, Dept Pathol, Songnam, South Korea

[10] Hanyang Univ, Coll Med, Dept Pathol, Seoul 133791, South Korea

[11] Chonbuk Natl Univ, Sch Med, Dept Pathol, Jeonju, South Korea

[12] Hallym Univ, Sacred Heart Hosp, Dept Pathol, Anyang, South Korea

[13] Univ Ulsan, Coll Med, Dept Pathol, Gangneung Asan Hosp, Kangnung, South Korea

[14] Bundang Jesaeng Gen Hosp, Dept Pathol, Songnam, South Korea

[15] Seoul Natl Univ, Coll Med, Dept Pathol, Seoul 151, South Korea

[16] Catholic Univ Daegu, Dept Pathol, Taegu, South Korea

[17] Yonsei Univ, Coll Med, Dept Pathol, Seoul, South Korea

[18] Inje Univ, Coll Med, Dept Pathol, Pusan, South Korea

[19] Chonnam Natl Univ, Sch Med, Dept Pathol, Kwangju, South Korea

来源：

HEPATO-GASTROENTEROLOGY | 2012年 / 59卷 / 119期

关键词：

Small intestine; Carcinoma; Mismatch repair; hMLH1; hMSH2; hMSH6; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; SMALL-BOWEL; DUODENAL CARCINOMAS; GENETIC ALTERATIONS; ADENOCARCINOMA; CANCER; METHYLATION; HYPERMETHYLATION; PROMOTER;

D O I：

10.5754/hge11601

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background/Aims: Although primary small intestinal carcinoma (SIC) is morphologically similar to colorectal carcinoma and shares many of the genetic changes of carcinogenesis, little is known about the role of defective mismatch repair (MMR) genes involved in the SIC. The aim of this study is to investigate the role of defective MMR genes and correlation between clinicopathological factors and loss of MMR protein in SIC. Methodology: A total of 195 SIC cases were collected from 20 institutions in Korea and tissue microarrays (TMA) were made. The loss of expression of hMLH1, hMSH2 and hMSH6 was examined by immunohistochemistry (IHC). Results: The loss of expression of hMLH1, hMSH2 and hMSH6 was identified in 25/193 (13.0%), 25/193 (13%) and 29/195 (15%), respectively. The loss of hMSH2 expression was associated with retroperitoneal seeding. Patients with loss of hMSH6 expression had a tendency to invade deeply and a higher frequency of pancreas invasion. The loss of hMSH6 expression was associated less frequently with peritumoral adenoma. There was no survival difference by MMR protein expression status. Conclusions: The loss of MMR protein was associated with some distinct clinicopathological features. MMR pathway seems to be major pathway in carcinogenesis of SICs. MMR defect seems to be related with sporadic-microsatellite instability (MSI).

引用

页码：2228 / 2232

页数：5

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